Mostrar el registro sencillo del ítem

dc.contributor.author
Coraglia, Ana Carina  
dc.contributor.author
Galassi, Nora Virginia  
dc.contributor.author
Fernández Romero, Diego S.  
dc.contributor.author
Juri, M. Cecilia  
dc.contributor.author
Felippo, Marta Elena  
dc.contributor.author
Malbrán, Alejandro  
dc.contributor.author
de Bracco, Maria M. E.  
dc.date.available
2018-04-03T18:58:31Z  
dc.date.issued
2016-04  
dc.identifier.citation
Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; et al.; Common variable immunodeficiency and circulating TFH; Hindawi; Journal of Immunology Research; 2016; 4-2016; 1-10  
dc.identifier.issn
2314-8861  
dc.identifier.uri
http://hdl.handle.net/11336/40551  
dc.description.abstract
CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Hindawi  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cvid  
dc.subject
B Lymphocytes  
dc.subject
Circulating Tfh  
dc.subject
Icos-Cd40l  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Common variable immunodeficiency and circulating TFH  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-03T18:26:27Z  
dc.journal.volume
2016  
dc.journal.pagination
1-10  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
London  
dc.description.fil
Fil: Coraglia, Ana Carina. Academia Nacional de Medicina de Buenos Aires; Argentina  
dc.description.fil
Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Fernández Romero, Diego S.. Unidad de Alergia, Asma e Inmunología Clínica; Argentina  
dc.description.fil
Fil: Juri, M. Cecilia. Unidad de Alergia, Asma e Inmunología Clínica; Argentina  
dc.description.fil
Fil: Felippo, Marta Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Malbrán, Alejandro. Unidad de Alergia, Asma e Inmunología Clínica; Argentina  
dc.description.fil
Fil: de Bracco, Maria M. E.. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.journal.title
Journal of Immunology Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2016/4951587  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2016/4951587/