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Artículo

Common variable immunodeficiency and circulating TFH

Coraglia, Ana CarinaIcon ; Galassi, Nora VirginiaIcon ; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta ElenaIcon ; Malbrán, AlejandroIcon ; de Bracco, Maria M. E.
Fecha de publicación: 04/2016
Editorial: Hindawi
Revista: Journal of Immunology Research
ISSN: 2314-8861
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.
Palabras clave: Cvid , B Lymphocytes , Circulating Tfh , Icos-Cd40l
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/40551
DOI: http://dx.doi.org/10.1155/2016/4951587
URL: https://www.hindawi.com/journals/jir/2016/4951587/
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; et al.; Common variable immunodeficiency and circulating TFH; Hindawi; Journal of Immunology Research; 2016; 4-2016; 1-10
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