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Artículo

ECLAMC study: Prevalence patterns of hypospadias in South America: Multi-national analysis over a 24-year period

Fernández, Nicolás; Pérez, Jaime; Monterrey, Pedro; Poletta, Fernando AdriánIcon ; Bägli, Darius J.; Lorenzo, Armando J.; Zarante, Ignacio
Fecha de publicación: 03/2017
Editorial: Sociedade Brasileira de Urologia
Revista: International Brazilian Journal of Urology
ISSN: 1677-5538
e-ISSN: 1677-6119
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

Objective: To evaluate prevalence trends of hypospadias in South-America it is essential to perform multicenter and multinational studies with the same methodology. Herein we present systematic data as part of an international multicenter initiative evaluating congenital malformations in South America over a 24-year period. Materials and Methods: A nested case-control study was conducted using the Latin American Collaborative Study of Congenital Malformations (ECLAMC), between January 1989 and December 2012. Cases were stratified as isolated (IH) and non-isolated hypospadias (NIH). Global prevalence was calculated and discriminated by country. Associations between birth weight and gestational age, and NIH distribution by associated abnormality and severity of hypospadias, were analyzed. Results: A total of 159 hospitals from six countries participated, reporting surveillance on 4.020.384 newborns. A total of 4.537 hypospadias cases were detected, with a global prevalence of 11.3/10.000 newborns. Trend analyses showed in Chile, Brazil and Uruguay a statistically significant increase in prevalence. Analysis of severity and associated anomalies did not to find an association for distal cases, but did for proximal (RR=1.64 [95% CI=1.33-2.03]). Conclusion: This is one of only a few Latin American multicenter studies reporting on the epidemiology of hypospadias in South America in the last two decades. Our data adds to evidence suggesting an increase in some countries in the region at different times. There were also variations in prevalence according to severity. This study adds to literature describing associated anomalies at a hospital-based level.
Palabras clave: Epidemiology , Hypospadias , Prevalence
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/40196
DOI: http://dx.doi.org/10.1590/S1677-5538.IBJU.2016.0002
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433373/
URL: http://www.intbrazjurol.com.br/pdf/vol43n02/Fernandez_325_334.pdf
URL: http://ref.scielo.org/pxq6gf
Colecciones
Articulos(CEMIC-CONICET)
Articulos de CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Citación
Fernández, Nicolás; Pérez, Jaime; Monterrey, Pedro; Poletta, Fernando Adrián; Bägli, Darius J.; et al.; ECLAMC study: Prevalence patterns of hypospadias in South America: Multi-national analysis over a 24-year period; Sociedade Brasileira de Urologia; International Brazilian Journal of Urology; 43; 2; 3-2017; 325-334
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