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dc.contributor.author
Denninghoff, Valeria Cecilia  
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Olivieri, E. H. R.  
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Fresno Rodríguez, Cristóbal  
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Uceda, Ana Margarita  
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Mota, L.  
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Suenaga, A. P.  
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Carraro, D. M.  
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Martins, V. R.  
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Avagnina, Alejandra  
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Soares, F. A.  
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Campos, A. H. J. Fróes Marques  
dc.date.available
2018-03-27T18:52:41Z  
dc.date.issued
2017-12  
dc.identifier.citation
Denninghoff, Valeria Cecilia; Olivieri, E. H. R.; Fresno Rodríguez, Cristóbal; Uceda, Ana Margarita; Mota, L.; et al.; Tissue alkalosis in cold-ischemia time; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-6; 10867  
dc.identifier.issn
2045-2322  
dc.identifier.uri
http://hdl.handle.net/11336/40193  
dc.description.abstract
The control of pre-Analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
Ischemia  
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Alkalosis  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Tissue alkalosis in cold-ischemia time  
dc.type
info:eu-repo/semantics/article  
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info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-27T14:52:51Z  
dc.journal.volume
7  
dc.journal.number
1  
dc.journal.pagination
1-6; 10867  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Denninghoff, Valeria Cecilia. A. C. Camargo Cancer Center; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina  
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Fil: Olivieri, E. H. R.. A. C. Camargo Cancer Center; Brasil  
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Fil: Fresno Rodríguez, Cristóbal. Secretaría de Salud. Instituto Nacional de Medicina Genómica; Argentina  
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Fil: Uceda, Ana Margarita. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina  
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Fil: Mota, L.. A. C. Camargo Cancer Center; Brasil  
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Fil: Suenaga, A. P.. A. C. Camargo Cancer Center; Brasil  
dc.description.fil
Fil: Carraro, D. M.. A. C. Camargo Cancer Center; Brasil  
dc.description.fil
Fil: Martins, V. R.. A. C. Camargo Cancer Center; Brasil  
dc.description.fil
Fil: Avagnina, Alejandra. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina  
dc.description.fil
Fil: Soares, F. A.. A. C. Camargo Cancer Center; Brasil  
dc.description.fil
Fil: Campos, A. H. J. Fróes Marques. A. C. Camargo Cancer Center; Brasil  
dc.journal.title
Scientific Reports  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-11284-z  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-11284-z