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dc.contributor.author
Denninghoff, Valeria Cecilia
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Olivieri, E. H. R.
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Fresno Rodríguez, Cristóbal
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Uceda, Ana Margarita
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Mota, L.
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Suenaga, A. P.
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Carraro, D. M.
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Martins, V. R.
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Avagnina, Alejandra
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Soares, F. A.
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Campos, A. H. J. Fróes Marques
dc.date.available
2018-03-27T18:52:41Z
dc.date.issued
2017-12
dc.identifier.citation
Denninghoff, Valeria Cecilia; Olivieri, E. H. R.; Fresno Rodríguez, Cristóbal; Uceda, Ana Margarita; Mota, L.; et al.; Tissue alkalosis in cold-ischemia time; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-6; 10867
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/40193
dc.description.abstract
The control of pre-Analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Ischemia
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Alkalosis
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Tissue alkalosis in cold-ischemia time
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-27T14:52:51Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-6; 10867
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Denninghoff, Valeria Cecilia. A. C. Camargo Cancer Center; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina
dc.description.fil
Fil: Olivieri, E. H. R.. A. C. Camargo Cancer Center; Brasil
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Fil: Fresno Rodríguez, Cristóbal. Secretaría de Salud. Instituto Nacional de Medicina Genómica; Argentina
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Fil: Uceda, Ana Margarita. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
dc.description.fil
Fil: Mota, L.. A. C. Camargo Cancer Center; Brasil
dc.description.fil
Fil: Suenaga, A. P.. A. C. Camargo Cancer Center; Brasil
dc.description.fil
Fil: Carraro, D. M.. A. C. Camargo Cancer Center; Brasil
dc.description.fil
Fil: Martins, V. R.. A. C. Camargo Cancer Center; Brasil
dc.description.fil
Fil: Avagnina, Alejandra. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
dc.description.fil
Fil: Soares, F. A.. A. C. Camargo Cancer Center; Brasil
dc.description.fil
Fil: Campos, A. H. J. Fróes Marques. A. C. Camargo Cancer Center; Brasil
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-11284-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-11284-z
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