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dc.contributor.author
Wan, Guoqiang
dc.contributor.author
Gomez Casati, Maria Eugenia
dc.contributor.author
Gigliello, Angelica R.
dc.contributor.author
Liberman, M. Charles
dc.contributor.author
Corfas, Gabriel
dc.date.available
2016-02-03T20:22:12Z
dc.date.issued
2014-10
dc.identifier.citation
Wan, Guoqiang; Gomez Casati, Maria Eugenia; Gigliello, Angelica R.; Liberman, M. Charles; Corfas, Gabriel; Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma; eLife Sciences Publications; elife; 3; e03564; 10-2014; 1-18
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/4007
dc.description.abstract
Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and the establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood. Using cell-specific inducible gene recombination in mice we found that, in the postnatal inner ear, Bbnf and Ntf3 are required for the formation and maintenance of hair cell ribbon synapses in the vestibular and cochlear epithelia, respectively. We also show that supporting cells in these epithelia are the key endogenous source of the neurotrophins. Using a new hair cell CreERT line with mosaic expression, we also found that Ntf3´s effect on cochlear synaptogenesis is highly localized. Moreover, supporting cell-derived Ntf3, but not Bbnf, promoted recovery of cochlear function and ribbon synapse regeneration after acoustic trauma. These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse density and synaptic regeneration after injury.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Hair Cells
dc.subject
Trauma
dc.subject
Ribbon Synapse
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
3
dc.journal.number
e03564
dc.journal.pagination
1-18
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Wan, Guoqiang. Boston Children; Estados Unidos. Harvard Medical School. Department of Neurology; Estados Unidos. University of Michigan. Department of Otolaryngology - Head and Neck Surgery. Kresge Hearing Research Institute; Estados Unidos
dc.description.fil
Fil: Gomez Casati, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Boston Children; Estados Unidos. Harvard Medical School. Department of Neurology; Estados Unidos
dc.description.fil
Fil: Gigliello, Angelica R.. Boston Children; Estados Unidos
dc.description.fil
Fil: Liberman, M. Charles. Harvard Medical School. Department of Otology and Laryngology; Estados Unidos. Massachusetts Eye and Ear Infirmary. Eaton Peabody Laboratories; Estados Unidos
dc.description.fil
Fil: Corfas, Gabriel. Boston Children; Estados Unidos. Harvard Medical School. Department of Neurology; Estados Unidos. University of Michigan. Department of Otolaryngology - Head and Neck Surgery. Kresge Hearing Research Institute; Estados Unidos
dc.journal.title
elife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://elifesciences.org/content/3/e03564
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.03564
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227045/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/2050-084X
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