Artículo
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
Wan, Guoqiang; Gomez Casati, Maria Eugenia
; Gigliello, Angelica R.; Liberman, M. Charles; Corfas, Gabriel
Fecha de publicación:
10/2014
Editorial:
eLife Sciences Publications
Revista:
elife
ISSN:
2050-084X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and the establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood. Using cell-specific inducible gene recombination in mice we found that, in the postnatal inner ear, Bbnf and Ntf3 are required for the formation and maintenance of hair cell ribbon synapses in the vestibular and cochlear epithelia, respectively. We also show that supporting cells in these epithelia are the key endogenous source of the neurotrophins. Using a new hair cell CreERT line with mosaic expression, we also found that Ntf3´s effect on cochlear synaptogenesis is highly localized. Moreover, supporting cell-derived Ntf3, but not Bbnf, promoted recovery of cochlear function and ribbon synapse regeneration after acoustic trauma. These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse density and synaptic regeneration after injury.
Palabras clave:
Hair Cells
,
Trauma
,
Ribbon Synapse
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Wan, Guoqiang; Gomez Casati, Maria Eugenia; Gigliello, Angelica R.; Liberman, M. Charles; Corfas, Gabriel; Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma; eLife Sciences Publications; elife; 3; e03564; 10-2014; 1-18
Compartir
Altmétricas