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dc.contributor.author
Erben, Esteban Daniel
dc.contributor.author
Nardelli, Sheila
dc.contributor.author
De Jesus, Teresa C. L.
dc.contributor.author
Schenkman, Sergio
dc.contributor.author
Tellez, Maria Teresa
dc.date.available
2016-02-02T20:46:17Z
dc.date.issued
2012-12-03
dc.identifier.citation
Erben, Esteban Daniel; Nardelli, Sheila; De Jesus, Teresa C. L.; Schenkman, Sergio; Tellez, Maria Teresa; Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation; Wiley; Journal of Eukaryotic Microbiology; 60; 1; 3-12-2012; 101-105
dc.identifier.issn
1066-5234
dc.identifier.uri
http://hdl.handle.net/11336/3974
dc.description.abstract
Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localization. Immunofluorescence analysis revealed that in contrast with Pin1-like proteins from diverse organisms, TcPin1 mainly localized in the cytoplasm and was excluded from the nuclei. In addition, RNAi-mediated downregulation of TbPin1 in Trypanosoma brucei did not abolish cell proliferation. Using yeast two-hybrid assay, we identified a MORN domain-containing protein as putative Pin1-binding partners. These data suggest that Pin1-mediated signaling mechanism plays a different role in protozoan parasites.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pin1-Type Peptidyl-Prolyl Isomerase
dc.subject
Trypansoma Cruzi
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
60
dc.journal.number
1
dc.journal.pagination
101-105
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Erben, Esteban Daniel. Zentrum fur Molekular Biologie Heidelberg; Alemania
dc.description.fil
Fil: Nardelli, Sheila. Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia; Brasil
dc.description.fil
Fil: De Jesus, Teresa C. L.. Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia; Brasil
dc.description.fil
Fil: Schenkman, Sergio. Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia; Brasil
dc.description.fil
Fil: Tellez, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
dc.journal.title
Journal of Eukaryotic Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jeu.12009/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/wos/http://dx.doi.org/DOI:10.1111/jeu.12009
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