Artículo
Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation
Erben, Esteban Daniel; Nardelli, Sheila; De Jesus, Teresa C. L.; Schenkman, Sergio; Tellez, Maria Teresa
Fecha de publicación:
03/12/2012
Editorial:
Wiley
Revista:
Journal of Eukaryotic Microbiology
ISSN:
1066-5234
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localization. Immunofluorescence analysis revealed that in contrast with Pin1-like proteins from diverse organisms, TcPin1 mainly localized in the cytoplasm and was excluded from the nuclei. In addition, RNAi-mediated downregulation of TbPin1 in Trypanosoma brucei did not abolish cell proliferation. Using yeast two-hybrid assay, we identified a MORN domain-containing protein as putative Pin1-binding partners. These data suggest that Pin1-mediated signaling mechanism plays a different role in protozoan parasites.
Palabras clave:
Pin1-Type Peptidyl-Prolyl Isomerase
,
Trypansoma Cruzi
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Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Erben, Esteban Daniel; Nardelli, Sheila; De Jesus, Teresa C. L.; Schenkman, Sergio; Tellez, Maria Teresa; Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation; Wiley; Journal of Eukaryotic Microbiology; 60; 1; 3-12-2012; 101-105
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