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Artículo

Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease

Baravalle, María EugeniaIcon ; Stassi, Antonela FlorenciaIcon ; Velázquez, Melisa María del LujánIcon ; Belotti, Eduardo MatíasIcon ; Rodríguez, Fernanda MarielIcon ; Ortega, Hugo HectorIcon ; Salvetti, Natalia RaquelIcon
Fecha de publicación: 08/2015
Editorial: Elsevier
Revista: Journal Of Comparative Pathology
ISSN: 0021-9975
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

A growing body of evidence suggests that ovulation shares many of the features of an inflammatory reaction and that cytokines play many diverse and important roles in reproductive biology. The aim of this study was to examine the expression of the pro-inflammatory cytokines interleukin (IL)-1α, IL-6 and tumour necrosis factor (TNF)-α in ovarian cells from cows with cystic ovarian disease (COD) as compared with that in ovarian structures from regularly cycling cows. Expression of genes encoding IL-1α, IL-6 and TNF-α was detected by real-time polymerase chain reaction in follicular cells from ovaries from healthy cows and cows with COD with no significant differences. However, immunohistochemistry showed increased expression of IL-1α, IL-6 and TNF-α in cystic follicles, suggesting that this expression may be related to the persistence of follicular cysts. The effect of COD was evident for IL-1α and TNF-α, and a follicular structure-disease interaction was observed in the expression of all the cytokines evaluated. Thus, altered expression of these proinflammatory cytokines may be related to ovulation failure and development of follicular cysts.
Palabras clave: Cow , Cytokine , Immunohistochemistry , Ovarian Cyst
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/39601
URL: https://www.sciencedirect.com/science/article/pii/S0021997515000754
DOI: http://dx.doi.org/10.1016/j.jcpa.2015.04.007
Colecciones
Articulos(ICIVET-LITORAL)
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Citación
Baravalle, María Eugenia; Stassi, Antonela Florencia; Velázquez, Melisa María del Luján; Belotti, Eduardo Matías; Rodríguez, Fernanda Mariel; et al.; Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease; Elsevier; Journal Of Comparative Pathology; 153; 2-3; 8-2015; 116-130
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