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dc.contributor.author
Peredo, Horacio Angel
dc.contributor.author
Lee, H.
dc.contributor.author
Donoso, Adriana Susana
dc.contributor.author
Andrade, V.
dc.contributor.author
Sánchez Eluchans, N.
dc.contributor.author
Puyó, Ana María
dc.date.available
2018-03-19T21:06:43Z
dc.date.issued
2015-04
dc.identifier.citation
Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; et al.; A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat; Blackwell Publishing; Autonomic and Autacoid Pharmacology; 34; 3-4; 4-2015; 35-40
dc.identifier.issn
1474-8673
dc.identifier.uri
http://hdl.handle.net/11336/39283
dc.description.abstract
In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fructose
dc.subject
High Fat
dc.subject
Hypertension
dc.subject
Metabolic Syndrome
dc.subject
Prostanoids
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-19T17:26:15Z
dc.journal.volume
34
dc.journal.number
3-4
dc.journal.pagination
35-40
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lee, H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Sánchez Eluchans, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Autonomic and Autacoid Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/aap.12021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/aap.12021


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