Artículo
A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
Peredo, Horacio Angel
; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; Puyó, Ana María
Fecha de publicación:
04/2015
Editorial:
Blackwell Publishing
Revista:
Autonomic and Autacoid Pharmacology
ISSN:
1474-8673
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
Palabras clave:
Fructose
,
High Fat
,
Hypertension
,
Metabolic Syndrome
,
Prostanoids
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Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; et al.; A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat; Blackwell Publishing; Autonomic and Autacoid Pharmacology; 34; 3-4; 4-2015; 35-40
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