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Artículo

Early administration of Enalapril prevents diastolic dysfunction and ventricular remodeling in rabbits with myocardial infarction

González, Germán EstebanIcon ; Wilensky, LucianaIcon ; Cassaglia, Pablo; Morales, Maria Celina; Gelpi, Ricardo JorgeIcon
Fecha de publicación: 05/2016
Editorial: Elsevier Science Inc
Revista: Cardiovascular Pathology
ISSN: 1054-8807
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Patología

Resumen

We aimed to investigate the role of early administration of Enalapril (Enal) on post-myocardial infarction (MI) ventricular remodeling and diastolic dysfunction in rabbits. White New Zealand rabbits that underwent coronary artery ligature or Sham were divided in three experimental groups: (1) Sham, (2) MI, and (3) MI + Enal. Enal was given by gavage at a dose of 10 mg/kg/day starting at 3 h after surgery for 35 days. At the end of the protocol, we measured (1) mean arterial pressure, (2) left ventricular (LV)+dP/dtmax, (3) LV end-diastolic pressure (LVEDP) and isovolumic relaxation (Tau), (4) LV dimensions, (5) LV ejection and shortening fraction, (6) infarct size (Masson's trichrome-stained slices), (7) fibrosis in the infarct and remote zone (Picrosirius red-stained slices), and (8) myocyte cross-sectional area (MCSA) in WGA-stained section. Enal reduced the mean arterial pressure by 30% as compared with untreated animals and Sham (P <.05). MI reduced LV + dP/dtmax and LV - dP/dtmax (mmHg/s), increased LVEDP (mmHg), Tau (ms), and t50 (ms) values, suggesting a decrease in the relaxation rate. LV end-diastolic dimension and LV end-systolic dimension (LVESD, mm) increased in untreated MI (P <.05 vs. Sham). In contrast, Enal markedly prevented post-MI diastolic dysfunction by significantly decrease LVEDP from 8.2 ± 0.2 to 5.1 ± 0.3 mmHg, Tau from 19.8 ± 0.8 to 15.3 ± 0.9 ms, and t50 from 12.4 ± 0.5 to 9.6 ± 0.8 ms as well as reduced LVESD from 15 ± 1.1 to 12 ± 0.8 mm (P <.05 MI vs. MI + Enal). Collagen concentration in the scar was unaffected, but chronic treatment with Enal prevented myocardial fibrosis and MCSA in the remote zone. In summary, chronic early administration of Enal to rabbits with experimental MI has a favorable effect on ventricular remodeling and diastolic function by reducing MCSA and fibrosis, without affecting the wound healing.
Palabras clave: Diastolic Function , Enalapril , Myocardial Infarction , Ventricular Remodeling
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38902
URL: https://www.sciencedirect.com/science/article/pii/S1054880716000107
DOI: http://dx.doi.org/10.1016/j.carpath.2016.01.004
Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
González, Germán Esteban; Wilensky, Luciana; Cassaglia, Pablo; Morales, Maria Celina; Gelpi, Ricardo Jorge; Early administration of Enalapril prevents diastolic dysfunction and ventricular remodeling in rabbits with myocardial infarction; Elsevier Science Inc; Cardiovascular Pathology; 25; 3; 5-2016; 208-213
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