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dc.contributor.author
Dropa, Milena  
dc.contributor.author
Ghiglione, Barbara  
dc.contributor.author
Matté, Maria Helena  
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Balsalobre, Livia Carminato  
dc.contributor.author
Lincopan, Nilton  
dc.contributor.author
Matté, Glavur Rogério  
dc.contributor.author
Gutkind, Gabriel Osvaldo  
dc.contributor.author
Power, Pablo  
dc.date.available
2018-03-14T19:14:43Z  
dc.date.issued
2015-03  
dc.identifier.citation
Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; et al.; Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 59; 3; 3-2015; 1815-1817  
dc.identifier.issn
0066-4804  
dc.identifier.uri
http://hdl.handle.net/11336/38773  
dc.description.abstract
CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society for Microbiology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ctx-M-131  
dc.subject
Asp240gly  
dc.subject
Providencia Rettgeri  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-13T18:12:28Z  
dc.journal.volume
59  
dc.journal.number
3  
dc.journal.pagination
1815-1817  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington, DC  
dc.description.fil
Fil: Dropa, Milena. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Ghiglione, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Matté, Maria Helena. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Balsalobre, Livia Carminato. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Matté, Glavur Rogério. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Antimicrobial Agents and Chemotherapy  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/59/3/1815.full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.04116-14  

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