Artículo

Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil

Dropa, Milena; Ghiglione, BarbaraIcon ; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; Matté, Glavur Rogério; Gutkind, Gabriel OsvaldoIcon ; Power, PabloIcon
Fecha de publicación: 03/2015
Editorial: American Society for Microbiology
Revista: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime.
Palabras clave: Ctx-M-131 , Asp240gly , Providencia Rettgeri
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38773
URL: http://aac.asm.org/content/59/3/1815.full
DOI: http://dx.doi.org/10.1128/AAC.04116-14
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Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; et al.; Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 59; 3; 3-2015; 1815-1817
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