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dc.contributor.author
Gruel, Nadège
dc.contributor.author
Fuhrmann, Laetitia
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dc.contributor.author
Lodillinsky, Catalina
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dc.contributor.author
Benhamo, Vanessa
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Mariani, Odette
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Cédenot, Aurélie
dc.contributor.author
Arnould, Laurent
dc.contributor.author
Macgrogan, Gaëtan
dc.contributor.author
Sastre-Garau, Xavier
dc.contributor.author
Chavrier, Philippe
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dc.contributor.author
Delattre, Olivier
dc.contributor.author
Vincent Salomon, Anne
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dc.date.available
2018-03-14T18:05:47Z
dc.date.issued
2016-02
dc.identifier.citation
Gruel, Nadège; Fuhrmann, Laetitia; Lodillinsky, Catalina; Benhamo, Vanessa; Mariani, Odette; et al.; LIN7A is a major determinant of cell-polarity defects in breast carcinomas; BioMed Central; Breast Cancer Research; 18; 1; 2-2016; 1-10
dc.identifier.issn
1465-5411
dc.identifier.uri
http://hdl.handle.net/11336/38755
dc.description.abstract
Background: Polarity defects are a hallmark of most carcinomas. Cells from invasive micropapillary carcinomas (IMPCs) of the breast are characterized by a striking cell polarity inversion and represent an interesting model for the analysis of polarity abnormalities. Methods: In-depth investigation of polarity proteins in 24 IMPCs and a gene expression profiling, comparing IMPC (n = 73) with invasive carcinomas of no special type (ICNST) (n = 51) have been performed. Results: IMPCs showed a profound disorganization of the investigated polarity proteins and revealed major abnormalities in their subcellular localization. Gene expression profiling experiments highlighted a number of deregulated genes in the IMPCs that have a role in apico-basal polarity, adhesion and migration. LIN7A, a Crumbs-complex polarity gene, was one of the most differentially over-expressed genes in the IMPCs. Upon LIN7A over-expression, we observed hyperproliferation, invasion and a complete absence of lumen formation, revealing strong polarity defects. Conclusion: This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Breast Cancer
dc.subject
Cell Polarity
dc.subject
Lin7a
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Micropapillary Carcinomas
dc.subject.classification
Oncología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
LIN7A is a major determinant of cell-polarity defects in breast carcinomas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-14T17:04:30Z
dc.journal.volume
18
dc.journal.number
1
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Gruel, Nadège. Institute Curie; Francia
dc.description.fil
Fil: Fuhrmann, Laetitia. Institute Curie; Francia
dc.description.fil
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Benhamo, Vanessa. Institute Curie; Francia
dc.description.fil
Fil: Mariani, Odette. Institute Curie; Francia
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Fil: Cédenot, Aurélie. Institute Curie; Francia
dc.description.fil
Fil: Arnould, Laurent. Centre Georges François Leclerc; Francia
dc.description.fil
Fil: Macgrogan, Gaëtan. Institut Bergonié; Francia
dc.description.fil
Fil: Sastre-Garau, Xavier. Institute Curie; Francia
dc.description.fil
Fil: Chavrier, Philippe. Institute Curie; Francia
dc.description.fil
Fil: Delattre, Olivier. Institute Curie; Francia
dc.description.fil
Fil: Vincent Salomon, Anne. Institute Curie; Francia
dc.journal.title
Breast Cancer Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s13058-016-0680-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0680-x
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