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dc.contributor.author
Báez Buitrago, Sandra Jimena
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Kanske, Philipp
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Matallana, Diana
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Montañes, Patricia
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Reyes, Pablo
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Slachevsky, Andrea
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Matus, Cristian
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Vigliecca, Nora Silvana
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Torralva, Teresa
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Manes, Facundo Francisco
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Ibáñez Barassi, Agustín Mariano
dc.date.available
2018-03-14T18:05:35Z
dc.date.issued
2016-04
dc.identifier.citation
Báez Buitrago, Sandra Jimena; Kanske, Philipp; Matallana, Diana; Montañes, Patricia; Reyes, Pablo; et al.; Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures; Karger; Neurodegenerative Diseases; 16; 3-4; 4-2016; 206-217
dc.identifier.issn
1660-2854
dc.identifier.uri
http://hdl.handle.net/11336/38754
dc.description.abstract
Background: Moral judgment has been proposed to rely on a distributed brain network. This function is impaired in behavioral variant frontotemporal dementia (bvFTD), a condition involving damage to some regions of this network. However, no studies have investigated moral judgment in bvFTD via structural neuroimaging. Methods: We compared the performance of 21 bvFTD patients and 19 controls on a moral judgment task involving scenarios that discriminate between the contributions of intentions and outcomes. Voxel-based morphometry was used to assess (a) the atrophy pattern in bvFTD patients, (b) associations between gray matter (GM) volume and moral judgments, and (c) structural differences between bvFTD subgroups (patients with relatively preserved moral judgment and patients with severer moral judgment impairments). Results: Patients judged attempted harm as more permissible and accidental harm as less permissible than controls. The groups' performance on accidental harm was associated with GM volume in the precuneus. In controls, it was al- so associated with the ventromedial prefrontal cortex (VMPFC). Also, both groups' performance on attempted harm was associated with GM volume in the temporoparietal junction. Patients exhibiting worse performance displayed smaller GM volumes in the precuneus and temporal pole. Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Behavioral Variant of Frontotemporal Dementia
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Magnetic Resonance Imaging
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Moral Judgment
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Structural Correlates
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Voxel-Based Morphometry
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Psicología
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Psicología
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CIENCIAS SOCIALES
dc.title
Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-12T19:23:58Z
dc.journal.volume
16
dc.journal.number
3-4
dc.journal.pagination
206-217
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile
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Fil: Kanske, Philipp. Max Planck Institute for Human Cognitive and Brain Sciences; Alemania
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Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia
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Fil: Montañes, Patricia. Universidad Nacional de Colombia; Colombia
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Fil: Reyes, Pablo. Pontificia Universidad Javeriana; Colombia
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Fil: Slachevsky, Andrea. Universidad de Chile; Chile. Clínica Alemana; Chile
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Fil: Matus, Cristian. Hospital de Carabineros; Chile. Fundación Médica San Cristobal; Chile
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Fil: Vigliecca, Nora Silvana. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Torralva, Teresa. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; Australia
dc.description.fil
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Diego Portales; Chile. Macquarie University; Australia. Universidad Autónoma del Caribe; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.journal.title
Neurodegenerative Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000441918
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/441918


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