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Artículo

Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures

Báez Buitrago, Sandra JimenaIcon ; Kanske, Philipp; Matallana, Diana; Montañes, Patricia; Reyes, Pablo; Slachevsky, Andrea; Matus, Cristian; Vigliecca, Nora SilvanaIcon ; Torralva, Teresa; Manes, Facundo FranciscoIcon ; Ibañez, Agustin MarianoIcon
Fecha de publicación: 04/2016
Editorial: Karger
Revista: Neurodegenerative Diseases
ISSN: 1660-2854
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Psicología

Resumen

Background: Moral judgment has been proposed to rely on a distributed brain network. This function is impaired in behavioral variant frontotemporal dementia (bvFTD), a condition involving damage to some regions of this network. However, no studies have investigated moral judgment in bvFTD via structural neuroimaging. Methods: We compared the performance of 21 bvFTD patients and 19 controls on a moral judgment task involving scenarios that discriminate between the contributions of intentions and outcomes. Voxel-based morphometry was used to assess (a) the atrophy pattern in bvFTD patients, (b) associations between gray matter (GM) volume and moral judgments, and (c) structural differences between bvFTD subgroups (patients with relatively preserved moral judgment and patients with severer moral judgment impairments). Results: Patients judged attempted harm as more permissible and accidental harm as less permissible than controls. The groups' performance on accidental harm was associated with GM volume in the precuneus. In controls, it was al- so associated with the ventromedial prefrontal cortex (VMPFC). Also, both groups' performance on attempted harm was associated with GM volume in the temporoparietal junction. Patients exhibiting worse performance displayed smaller GM volumes in the precuneus and temporal pole. Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.
Palabras clave: Behavioral Variant of Frontotemporal Dementia , Magnetic Resonance Imaging , Moral Judgment , Structural Correlates , Voxel-Based Morphometry
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38754
DOI: http://dx.doi.org/10.1159/000441918
URL: https://www.karger.com/Article/Abstract/441918
Colecciones
Articulos(IDH)
Articulos de INSTITUTO DE HUMANIDADES
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Báez Buitrago, Sandra Jimena; Kanske, Philipp; Matallana, Diana; Montañes, Patricia; Reyes, Pablo; et al.; Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures; Karger; Neurodegenerative Diseases; 16; 3-4; 4-2016; 206-217
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