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dc.contributor.author
Monti, Jaime M.
dc.contributor.author
BaHammam, Ahmed S.
dc.contributor.author
Pandi-Perumal, Seithikurippu R.
dc.contributor.author
Bromundt, Vivien
dc.contributor.author
Spence, D. Warren
dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Brown, Gregory M.
dc.date.available
2016-01-27T20:02:07Z
dc.date.issued
2013-01-11
dc.identifier.citation
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; et al.; Sleep and circadian rhythm dysregulation in schizophrenia; Elsevier; Progress of Neuro-Psychopharmacology and Biological Psychiatry; 43; 11-1-2013; 209-216
dc.identifier.issn
0278-5846
dc.identifier.uri
http://hdl.handle.net/11336/3858
dc.description.abstract
Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Circadian Rhythms
dc.subject
Schizophrenia
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Sleep
dc.subject.classification
Psiquiatría
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sleep and circadian rhythm dysregulation in schizophrenia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
43
dc.journal.pagination
209-216
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Monti, Jaime M.. Hospital de Clínicas. Departamento de Farmacología y Terapéutica; Uruguay
dc.description.fil
Fil: BaHammam, Ahmed S.. King Saud University. University Sleep Disorders Center; Arabia Saudita
dc.description.fil
Fil: Pandi-Perumal, Seithikurippu R.. Somnogen Canada Inc.; Canadá
dc.description.fil
Fil: Bromundt, Vivien. University of Basel. Psychiatric Hospital. Centre for Chronobiology; Suiza
dc.description.fil
Fil: Spence, D. Warren.
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Brown, Gregory M.. University of Toronto. Centre for Addiction and Mental Health; Canadá
dc.journal.title
Progress of Neuro-Psychopharmacology and Biological Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584612003417
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2012.12.021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/0278-5846
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