Artículo
Sleep and circadian rhythm dysregulation in schizophrenia
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; Cardinali, Daniel Pedro
; Brown, Gregory M.
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Fecha de publicación:
11/01/2013
Editorial:
Elsevier
Revista:
Progress of Neuro-Psychopharmacology and Biological Psychiatry
ISSN:
0278-5846
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Palabras clave:
Circadian Rhythms
,
Schizophrenia
,
Sleep
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Citación
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; et al.; Sleep and circadian rhythm dysregulation in schizophrenia; Elsevier; Progress of Neuro-Psychopharmacology and Biological Psychiatry; 43; 11-1-2013; 209-216
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