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dc.contributor.author
Olivera, Elías R.
dc.contributor.author
Carnicero, David
dc.contributor.author
Jodra, Ruth
dc.contributor.author
Miñambres, Baltasar
dc.contributor.author
Garcia, Belén
dc.contributor.author
Abraham, Gustavo Abel
dc.contributor.author
Gallardo, Alberto
dc.contributor.author
San Roman, Julio
dc.contributor.author
García, José
dc.contributor.author
Naharro, Germán
dc.contributor.author
Luengo, José M.
dc.date.available
2018-02-08T21:23:03Z
dc.date.issued
2008-07-07
dc.identifier.citation
Olivera, Elías R.; Carnicero, David; Jodra, Ruth; Miñambres, Baltasar; Garcia, Belén; et al.; Genetically engineered Pseudomonas: a factory of new bioplastics with broad applications; Wiley Blackwell Publishing, Inc; Environmental Microbiology; 3; 10; 7-7-2008; 612-618
dc.identifier.issn
1462-2912
dc.identifier.uri
http://hdl.handle.net/11336/36252
dc.description.abstract
New bioplastics containing aromatic or mixtures of aliphatic and aromatic monomers have been obtained using genetically engineered strains of Pseudomonas putida. The mutation (–) or deletion (Δ) of some of the genes involved in the β-oxidation pathway (fadA−, fadB−ΔfadA or Δfad BA mutants) elicits a strong intracellular accumulation of unusual homo- or co-polymers that dramatically alter the morphology of these bacteria, as more than 90% of the cytoplasm is occupied by these macromolecules. The introduction of a blockade in the β-oxidation pathway, or in other related catabolic routes, has allowed the synthesis of polymers other than those accumulated in the wild type (with regard to both monomer size and relative percentage), the accumulation of certain intermediates that are rapidly catabolized in the wild type and the accumulation in the culture broths of end catabolites that, as in the case of phenylacetic acid, phenylbutyric acid, trans-cinnamic acid or their derivatives, have important medical or pharmaceutical applications (antitumoral, analgesic, radiopotentiators, chemopreventive or antihelmintic). Furthermore, using one of these polyesters (poly 3-hydroxy-6-phenylhexanoate), we obtained polymeric microspheres that could be used as drug vehicles.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetically engineered Pseudomonas: a factory of new bioplastics with broad applications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-02T19:44:32Z
dc.journal.volume
3
dc.journal.number
10
dc.journal.pagination
612-618
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Olivera, Elías R.. Universidad de León; España
dc.description.fil
Fil: Carnicero, David. Universidad de León; España
dc.description.fil
Fil: Jodra, Ruth. Universidad de León; España
dc.description.fil
Fil: Miñambres, Baltasar. Universidad de León; España
dc.description.fil
Fil: Garcia, Belén. Universidad de León; España
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Gallardo, Alberto. Instituto de Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: San Roman, Julio. Instituto de Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: García, José. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
dc.description.fil
Fil: Naharro, Germán. Universidad de León; España
dc.description.fil
Fil: Luengo, José M.. Universidad de León; España
dc.journal.title
Environmental Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1046/j.1462-2920.2001.00224.x/abstract;jsessionid=B459D265252547C433AF3AF6725A3390.f02t02
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1046/j.1462-2920.2001.00224.x
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