Mostrar el registro sencillo del ítem

dc.contributor.author
Dolfi, Sonia C.  
dc.contributor.author
Jager, Adriana Valeria  
dc.contributor.author
Medina, Daniel J.  
dc.contributor.author
Haffty, Bruce G.  
dc.contributor.author
Yang, Jin Ming  
dc.contributor.author
Hirshfield, Kim M.  
dc.date.available
2018-01-12T19:41:50Z  
dc.date.issued
2014-08  
dc.identifier.citation
Dolfi, Sonia C.; Jager, Adriana Valeria; Medina, Daniel J.; Haffty, Bruce G.; Yang, Jin Ming; et al.; Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs; Elsevier Ireland; Cancer Letters; 350; 8-2014; 52-60  
dc.identifier.issn
0304-3835  
dc.identifier.uri
http://hdl.handle.net/11336/33148  
dc.description.abstract
The human homologue of mouse double minute 2 (MDM2) is overexpressed in tumors and contributes to tumorigenesis through inhibition of p53 activity. We investigated the effect of the anti-estrogen fulvestrant on MDM2 expression and sensitivity of estrogen receptor positive human breast cancer cell lines to chemotherapeutics. Fulvestrant down-regulated MDM2 through increased protein turnover. Fulvestrant blocked estrogen-dependent up-regulation of MDM2 and decreased basal expression of MDM2 in the absence of estradiol. As combinations of fulvestrant with doxorubicin, etoposide or paclitaxel were synergistic, altering cell cycle distribution and increasing cell death, this provides rationale for testing combinatorial chemotherapy with fulvestrant as a novel therapeutic strategy for patients with advanced breast cancer.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Fulvestrant  
dc.subject
Mdm2  
dc.subject
Chemotherapy  
dc.subject
Estrogen Receptor  
dc.subject
Breast Cancer  
dc.subject.classification
Salud Ocupacional  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-01-12T16:16:37Z  
dc.journal.volume
350  
dc.journal.pagination
52-60  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Shannon  
dc.description.fil
Fil: Dolfi, Sonia C.. Rutgers Cancer Institute of New Jersey; Estados Unidos  
dc.description.fil
Fil: Jager, Adriana Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.description.fil
Fil: Medina, Daniel J.. Rutgers Cancer Institute of New Jersey; Estados Unidos  
dc.description.fil
Fil: Haffty, Bruce G.. Rutgers Cancer Institute of New Jersey; Estados Unidos  
dc.description.fil
Fil: Yang, Jin Ming. State University of Pennsylvania; Estados Unidos  
dc.description.fil
Fil: Hirshfield, Kim M.. Rutgers Cancer Institute of New Jersey; Estados Unidos  
dc.journal.title
Cancer Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304383514002158  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.canlet.2014.04.009