Artículo
Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs
Dolfi, Sonia C.; Jager, Adriana Valeria
; Medina, Daniel J.; Haffty, Bruce G.; Yang, Jin Ming; Hirshfield, Kim M.
Fecha de publicación:
08/2014
Editorial:
Elsevier Ireland
Revista:
Cancer Letters
ISSN:
0304-3835
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The human homologue of mouse double minute 2 (MDM2) is overexpressed in tumors and contributes to tumorigenesis through inhibition of p53 activity. We investigated the effect of the anti-estrogen fulvestrant on MDM2 expression and sensitivity of estrogen receptor positive human breast cancer cell lines to chemotherapeutics. Fulvestrant down-regulated MDM2 through increased protein turnover. Fulvestrant blocked estrogen-dependent up-regulation of MDM2 and decreased basal expression of MDM2 in the absence of estradiol. As combinations of fulvestrant with doxorubicin, etoposide or paclitaxel were synergistic, altering cell cycle distribution and increasing cell death, this provides rationale for testing combinatorial chemotherapy with fulvestrant as a novel therapeutic strategy for patients with advanced breast cancer.
Palabras clave:
Fulvestrant
,
Mdm2
,
Chemotherapy
,
Estrogen Receptor
,
Breast Cancer
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIB-INTECH)
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Citación
Dolfi, Sonia C.; Jager, Adriana Valeria; Medina, Daniel J.; Haffty, Bruce G.; Yang, Jin Ming; et al.; Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs; Elsevier Ireland; Cancer Letters; 350; 8-2014; 52-60
Compartir
Altmétricas