Mostrar el registro sencillo del ítem
dc.contributor.author
Wang, HongBin
dc.contributor.author
Gutierrez Uzquiza, Alvaro
dc.contributor.author
Garg, Rachana
dc.contributor.author
Barrio Real, Laura
dc.contributor.author
Abera, Mahlet B
dc.contributor.author
Lopez Haber, Cynthia
dc.contributor.author
Rosemblit, Cinthia
dc.contributor.author
Lu, Huaisheng
dc.contributor.author
Abba, Martín Carlos
dc.contributor.author
Kazanietz, Marcelo G.
dc.date.available
2018-01-11T17:06:50Z
dc.date.issued
2014-07
dc.identifier.citation
Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
dc.identifier.issn
1083-351X
dc.identifier.uri
http://hdl.handle.net/11336/32973
dc.description.abstract
Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Biochemistry and Molecular Biology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Breast Cancer
dc.subject
Diacylglycerol
dc.subject
Gene Expression
dc.subject
Protein Kinase C Epsilon
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-08T18:43:14Z
dc.journal.volume
289
dc.journal.pagination
19823-19838
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Wang, HongBin. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Gutierrez Uzquiza, Alvaro. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Garg, Rachana. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Barrio Real, Laura. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Abera, Mahlet B. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Lopez Haber, Cynthia. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Rosemblit, Cinthia. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Lu, Huaisheng. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
dc.description.fil
Fil: Kazanietz, Marcelo G.. University of Pennsylvania; Estados Unidos
dc.journal.title
Journal Of Biological Chemistry (online)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M114.548446
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/28/19823
Archivos asociados
Tamaño:
2.397Mb
Formato:
PDF