Artículo

Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins

Wang, HongBin; Gutierrez Uzquiza, Alvaro; Garg, Rachana; Barrio Real, Laura; Abera, Mahlet B; Lopez Haber, Cynthia; Rosemblit, CinthiaIcon ; Lu, Huaisheng; Abba, Martín CarlosIcon ; Kazanietz, Marcelo G.
Fecha de publicación: 07/2014
Editorial: American Society for Biochemistry and Molecular Biology
Revista: Journal Of Biological Chemistry (online)
ISSN: 1083-351X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
Palabras clave: Breast Cancer , Diacylglycerol , Gene Expression , Protein Kinase C Epsilon
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/32973
DOI: http://dx.doi.org/10.1074/jbc.M114.548446
URL: http://www.jbc.org/content/289/28/19823
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
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