Artículo
Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus
Castro, Jose Alberto
; Montalto, Maria
; Fanelli, Silvia Laura
; Cignoli de Ferreyra, Elida; Diaz, Edith Graciela
; Castro, Jose Alberto
Fecha de publicación:
09/2003
Editorial:
Elsevier Ireland
Revista:
Toxicology
ISSN:
0300-483X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Benznidazole (Bz) is a drug used in the chemotherapy of the acute and intermediate phases of Chagas’ disease (American Trypanosomiasis), an endemic parasitic disease afflicting more than 16 million people in Latin America. Serious toxic side effects of Bz have been reported in treated human beings and in experimental animals. Bz toxicity would be linked to its nitroreductive bioactivation to reactive intermediates and to the corresponding amine known to occur in vivo and mediated by different enzymatic systems. In the present study the presence of Bz nitroreductases in rat esophagus and the occurrence of Bz induced esophageal cell injury are described. Already 1 and 3 h after an intragastric Bz administration to Sprague–Dawley male rats (240–260 g body weight) at a dose of 100 mg/kg esophageal levels of the drug were 66.4±4.0 and 149.2±14.3 nmol per g tissue, respectively. The esophageal mucosa homogenates exhibited Bz nitroreductase activity attributable to the participation of cytochrome P450 reductase and xanthine oxidoreductase (XOR). The ultrastructural observation of esophageal tissue from Bz treated animals 24 h after its administration evidenced: detachment and conglomeration of polyribosomes, reduction in the presence of desmosomes and of the amount of bacteria on its surface. The potential significance of these alterations is not fully clear at present. However, these deleterious effects might be additive or synergistic with those induced by the evolution of the disease.
Palabras clave:
Benznidazole
,
Chagas Disease
,
Toxic Side Effects
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(ILPLA)
Articulos de INST.DE LIMNOLOGIA "DR. RAUL A. RINGUELET"
Articulos de INST.DE LIMNOLOGIA "DR. RAUL A. RINGUELET"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Articulos(UNIDEF)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO ESTRATEGICOS PARA LA DEFENSA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO ESTRATEGICOS PARA LA DEFENSA
Citación
Castro, Jose Alberto; Montalto, Maria; Fanelli, Silvia Laura; Cignoli de Ferreyra, Elida; Diaz, Edith Graciela; et al.; Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus; Elsevier Ireland; Toxicology; 191; 2-3; 9-2003; 189-198
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