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dc.contributor.author Rojas Delgado, Ricardo
dc.contributor.author Jimenez Kairuz, Alvaro Federico
dc.contributor.author Manzo, Ruben Hilario
dc.contributor.author Giacomelli, Carla Eugenia
dc.date.available 2017-12-26T18:33:56Z
dc.date.issued 2014-09
dc.identifier.citation Manzo, Ruben Hilario; Giacomelli, Carla Eugenia; Jimenez Kairuz, Alvaro Federico; Rojas Delgado, Ricardo; Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 463; 9-2014; 37-43
dc.identifier.issn 0927-7757
dc.identifier.uri http://hdl.handle.net/11336/31555
dc.description.abstract This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Zeta potential
dc.subject organic/inorganic hybrids
dc.subject hydrophobic interactions
dc.subject release mechanism
dc.subject Kinetic
dc.subject.classification Otras Ciencias Químicas
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-12-21T16:59:42Z
dc.journal.volume 463
dc.journal.pagination 37-43
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil Fil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.journal.title Colloids and Surfaces A: Physicochemical and Engineering Aspects
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfa.2014.09.031
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0927775714007535
dc.conicet.fuente individual


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  • Articulos(UNITEFA) [130]
    Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
  • Articulos(INFIQC) [772]
    Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)