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Artículo

Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity

Rojas Delgado, RicardoIcon ; Jimenez Kairuz, Alvaro FedericoIcon ; Manzo, Ruben HilarioIcon ; Giacomelli, Carla EugeniaIcon
Fecha de publicación: 09/2014
Editorial: Elsevier Science
Revista: Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN: 0927-7757
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

This work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42− ions and the release rate was determined by the drug polarity. In acidic medium, weathering was the main release mechanism. However, additional processes (anion exchange, drug solubilization) were concurrent in the latter media, the overall mechanism and release rate being dependent on the drug solubility.
Palabras clave: Zeta Potential , Organic/Inorganic Hybrids , Hydrophobic Interactions , Release Mechanism , Kinetic
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/31555
DOI: http://dx.doi.org/10.1016/j.colsurfa.2014.09.031
URL: http://www.sciencedirect.com/science/article/pii/S0927775714007535
Colecciones
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Manzo, Ruben Hilario; Giacomelli, Carla Eugenia; Jimenez Kairuz, Alvaro Federico; Rojas Delgado, Ricardo; Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 463; 9-2014; 37-43
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