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Artículo

Molecular mechanisms involved in mammalian gamete fusion

Cuasnicu, Patricia SaraIcon ; Ellerman, Diego Andrés; Cohen, Debora JuanaIcon ; Busso, Dolores; Morgenfeld, Mauro MiguelIcon ; Da Ros, Vanina GabrielaIcon
Fecha de publicación: 11/2001
Editorial: Elsevier Science Inc
Revista: Archives Of Medical Research (eletronico)
ISSN: 0188-4409
e-ISSN: 1873-5487
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Reproductiva

Resumen

Fusion between gametes is a key event in the fertilization process involving the interaction of specific domains of the sperm and egg plasma membranes. During recent years, efforts have been made toward the identification of the specific molecular components involved in this event. The present work will focus on the best characterized candidates for mediating gamete membrane fusion in mammals. These molecules include members of the ADAM (a disintegrin and a metalloprotease domain) family, i.e., testicular proteins fertilin alpha, fertilin beta, and cyritestin, which are thought to interact with integrins in the egg plasma membrane through their disintegrin domains, and a member of the cysteine-rich secretory proteins (CRISP) family, i.e., epididymal protein DE, which participates in an event subsequent to sperm-egg binding and leading to fusion through specific complementary sites localized on the fusogenic area of the egg surface. The identification and characterization of these molecules will contribute not only to a better understanding of the molecular mechanisms underlying mammalian sperm-egg fusion but also to the development of new methods for both fertility regulation and diagnosis and treatment of human infertility.
Palabras clave: Sperm-Egg Binding , Fertilin , Cyritestin , Fertilization
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/31335
URL: http://www.arcmedres.com/article/S0188-4409(01)00321-6/abstract
DOI: http://dx.doi.org/10.1016/S0188-4409(01)00321-6
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Da Ros, Vanina Gabriela; Morgenfeld, Mauro Miguel; Busso, Dolores; Cohen, Debora Juana; Ellerman, Diego Andrés; Cuasnicu, Patricia Sara; et al.; Molecular mechanisms involved in mammalian gamete fusion; Elsevier Science Inc; Archives Of Medical Research (eletronico); 32; 6; 11-2001; 614-618
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