Artículo
A Validated Reversed-Phase HPLC Method for the Determination of Atorvastatin Calcium in Tablets
Simionato, Laura Daniela; Ferello, L.; Stamer. S.; Repetto, M. F.; Zubata, P. D.; Segall, Adriana Ines
Fecha de publicación:
09/2014
Editorial:
Austin Publishing Group
Revista:
Austin Chromatography
ISSN:
2379-7975
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A Reversed-Phase Liquid Chromatographic (RP-LC) assay method was developed for the quantitative determination of atorvastatin calcium in the presence of its degradation products. The assay involved an isocratic elution of atorvastatin calcium in a LiChroCARTR 250*4 mm HPLC Cartridge LiChrospherR 100 RP-18 (5 μm) column using a mobile phase consisting of 0.1% acetic acid solution: acetonitrile (45:55, v/v), pH = 3.8. The flow rate was 0.8 mL/min and the analytes monitored at 246 nm. The assay method was found to be linear from 8.13 to 23.77 μg/mL. All the validation parameters were within the acceptance range. The developed method was successfully applied to estimate the amount of atorvastatin calcium in tablets.
Palabras clave:
Atorvastatin Calcium
,
Rp-Hplc
,
Tablets Assay
Archivos asociados
Tamaño:
1.682Mb
Formato:
PDF
Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Simionato, Laura Daniela; Ferello, L.; Stamer. S.; Repetto, M. F.; Zubata, P. D.; et al.; A Validated Reversed-Phase HPLC Method for the Determination of Atorvastatin Calcium in Tablets; Austin Publishing Group; Austin Chromatography; 1; 1; 9-2014; 1-4
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