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dc.contributor.author
Terrizzi, Antonela Romina
dc.contributor.author
Fernández Solari, José Javier
dc.contributor.author
Lee, Ching Ming
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Martinez, Maria del Pilar
dc.contributor.author
Conti, María Inés
dc.date.available
2017-12-12T19:39:15Z
dc.date.issued
2014-09
dc.identifier.citation
Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Martinez, Maria del Pilar; Conti, María Inés; Lead Intoxication under Environmental Hypoxia Impairs Oral Health; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 77; 21; 9-2014; 1304-1310
dc.identifier.issn
1528-7394
dc.identifier.uri
http://hdl.handle.net/11336/30339
dc.description.abstract
We have reported that chronic lead intoxication under hypoxic environment induces alveolar bone loss that can lead to periodontal damage with the subsequent loss of teeth. The aim of the present study was to assess the modification of oral inflammatory parameters involved in the pathogenesis of periodontitis in the same experimental model. In gingival tissue, hypoxia increased inducible nitric oxid synthase (iNOS) activity (p < .01) and meanwhile lead decreased prostaglandin E2 (PGE2) content (p < .05). In submandibular gland (SMG), iNOS activity was enhanced by lead and PGE2 content was increased by both lead and hypoxia (p < .01) and even more by combined treatments (p < .001). In the SMG, hypoxia stimulated angiogenesis (p < .01) with blood extravasation. Adrenal glands were 22% bigger in those animals exposed to lead under hypoxic conditions. Results suggest a wide participation of inflammatory markers that mediate alveolar bone loss induced by these environmental conditions. The lack of information regarding oral health in lead-contaminated populations that coexist with hypoxia induced us to evaluate the alteration of inflammatory parameters in rat oral tissues to elucidate the link between periodontal damage and these environmental conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lead
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Hypoxia
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Bone
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Periodontitis
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lead Intoxication under Environmental Hypoxia Impairs Oral Health
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T18:27:51Z
dc.journal.volume
77
dc.journal.number
21
dc.journal.pagination
1304-1310
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
dc.description.fil
Fil: Martinez, Maria del Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Conti, María Inés. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
dc.journal.title
Journal of Toxicology and Environmental Health-Part A-Current Issues
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/15287394.2014.938209
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/15287394.2014.938209
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