Artículo
Lead Intoxication under Environmental Hypoxia Impairs Oral Health
Terrizzi, Antonela Romina
; Fernández Solari, José Javier
; Lee, Ching Ming; Martinez, Maria del Pilar; Conti, María Inés
Fecha de publicación:
09/2014
Editorial:
Taylor & Francis
Revista:
Journal of Toxicology and Environmental Health-Part A-Current Issues
ISSN:
1528-7394
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We have reported that chronic lead intoxication under hypoxic environment induces alveolar bone loss that can lead to periodontal damage with the subsequent loss of teeth. The aim of the present study was to assess the modification of oral inflammatory parameters involved in the pathogenesis of periodontitis in the same experimental model. In gingival tissue, hypoxia increased inducible nitric oxid synthase (iNOS) activity (p < .01) and meanwhile lead decreased prostaglandin E2 (PGE2) content (p < .05). In submandibular gland (SMG), iNOS activity was enhanced by lead and PGE2 content was increased by both lead and hypoxia (p < .01) and even more by combined treatments (p < .001). In the SMG, hypoxia stimulated angiogenesis (p < .01) with blood extravasation. Adrenal glands were 22% bigger in those animals exposed to lead under hypoxic conditions. Results suggest a wide participation of inflammatory markers that mediate alveolar bone loss induced by these environmental conditions. The lack of information regarding oral health in lead-contaminated populations that coexist with hypoxia induced us to evaluate the alteration of inflammatory parameters in rat oral tissues to elucidate the link between periodontal damage and these environmental conditions.
Palabras clave:
Lead
,
Hypoxia
,
Bone
,
Periodontitis
Archivos asociados
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Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Martinez, Maria del Pilar; Conti, María Inés; Lead Intoxication under Environmental Hypoxia Impairs Oral Health; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 77; 21; 9-2014; 1304-1310
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