Artículo
Iron (II)-Catalysed Synthesis of alfa-aryl and alfa-alkylthioacetylamides
Murguia, Marcelo Cesar
; Ricci, Claudia Guadalupe; Cabrera, Maria Ines
; Luna, Julio Alberto
; Grau, Ricardo José Antonio
Fecha de publicación:
12/2001
Editorial:
Elsevier Science
Revista:
Journal of Molecular Catalysis A: Chemical
ISSN:
1381-1169
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The potential of iron(II)-catalysed reactions the synthesis of α-aryl and α-alkyl thioacetylamides from acetylthiomides is reported. Iron(II) ion efficiently catalyses reactions of iodobenzene 1a or 1-iodoadamantane 1b with N-thioacetylmorpholine anion 2 in DMSO. Ferrous bromide amounts in the 0.6–1.6 mol% range are large enough to reach yields of 86% of α-phenil-N-thioacetylmorpholine 3a and 65% of α-(1-adamanthyl)-N-thioacetyl-morpholine 3b. These catalytic reactions are more easily handled than photoinduced reactions, and provide a useful route to the synthesis of α-aryl and α-alkyl thioacetylamides from acetylthiomides without the need for special photochemical devices. A possible reaction pathway is suggested for the iron(II)-catalysed process involving iron-thioamide enolate complexes.
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Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Murguia, Marcelo Cesar; Ricci, Claudia Guadalupe; Cabrera, Maria Ines; Luna, Julio Alberto; Grau, Ricardo José Antonio; Iron (II)-Catalysed Synthesis of alfa-aryl and alfa-alkylthioacetylamides; Elsevier Science; Journal of Molecular Catalysis A: Chemical; 165; 12-2001; 113-120
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