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dc.contributor.author
Ceseña, Teresa I.
dc.contributor.author
Cui, Tracy Xiao
dc.contributor.author
Piwien Pilipuk, Graciela
dc.contributor.author
Kaplani, Julianne
dc.contributor.author
Calinescu, Anda Alexandra
dc.contributor.author
Huo, Jeffrey S.
dc.contributor.author
Iñiguez Lluhí, Jorge A.
dc.contributor.author
Kwok, Roland
dc.contributor.author
Schwartz, Jessica
dc.date.available
2017-11-18T12:51:36Z
dc.date.issued
2007
dc.identifier.citation
Ceseña, Teresa I.; Cui, Tracy Xiao; Piwien Pilipuk, Graciela; Kaplani, Julianne; Calinescu, Anda Alexandra; et al.; Multiple mechanisms of growth hormone-regulated gene transcription; Elsevier; Molecular Genetics And Metabolism; 90; 2; -1-2007; 126-133
dc.identifier.issn
1096-7192
dc.identifier.uri
http://hdl.handle.net/11336/28539
dc.description.abstract
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein complexes involving transcription factors, co-regulators and additional nuclear proteins; these serve as targets for regulation by hormones and signaling pathways. Evidence that GH regulates transcription at multiple levels is exemplified by analysis of the proto-oncogene c-fos. Among the GH-regulated transcription factors on c-fos, C/EBPbeta appears to be key, since depletion of C/EBPbeta by RNA interference blocks the stimulation of c-fos by GH. The phosphorylation state of C/EBPbeta and its ability to activate transcription are regulated by GH through MAPK and PI3K/Akt-mediated signaling cascades. The acetylation of C/EBPbeta also contributes to its ability to activate c-fos transcription. These and other post-translational modifications of C/EBPbeta appear to be integrated for regulation of transcription by GH. The formation of nuclear proteins into complexes associated with DNA-bound transcription factors is also regulated by GH. Both C/EBPbeta and the co-activator p300 are recruited to c-fos in response to GH, altering c-fos promoter activation. In addition, GH rapidly induces spatio-temporal re-localization of C/EBPbeta within the nucleus. Thus, GH-regulated gene transcription mediated by C/EBPbeta reflects the integration of diverse mechanisms including post-translational modifications, modulation of protein complexes associated with DNA and re-localization of gene regulatory proteins. Similar integration involving other transcription factors, including Stats, appears to be a feature of regulation by GH of other gene targets.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gh
dc.subject
C/Ebpbeta
dc.subject
Gene Expression
dc.subject
Nucleoproteins
dc.subject
Transcription Factors
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Multiple mechanisms of growth hormone-regulated gene transcription
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-12T19:48:16Z
dc.identifier.eissn
1096-7206
dc.journal.volume
90
dc.journal.number
2
dc.journal.pagination
126-133
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ceseña, Teresa I.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Cui, Tracy Xiao. University of Michigan; Estados Unidos
dc.description.fil
Fil: Piwien Pilipuk, Graciela. Fundación Instituto Leloir; Argentina
dc.description.fil
Fil: Kaplani, Julianne. University of Michigan; Estados Unidos
dc.description.fil
Fil: Calinescu, Anda Alexandra. Michigan State University; Estados Unidos
dc.description.fil
Fil: Huo, Jeffrey S.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Iñiguez Lluhí, Jorge A.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Kwok, Roland. University of Michigan; Estados Unidos
dc.description.fil
Fil: Schwartz, Jessica. University of Michigan; Estados Unidos
dc.journal.title
Molecular Genetics And Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mgmjournal.com/article/S1096-7192(06)00349-0/fulltext
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ymgme.2006.10.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986646/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/17129742


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