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Artículo

Multiple mechanisms of growth hormone-regulated gene transcription

Ceseña, Teresa I.; Cui, Tracy Xiao; Piwien Pilipuk, GracielaIcon ; Kaplani, Julianne; Calinescu, Anda Alexandra; Huo, Jeffrey S.; Iñiguez Lluhí, Jorge A.; Kwok, Roland; Schwartz, Jessica
Fecha de publicación: 2007
Editorial: Elsevier
Revista: Molecular Genetics And Metabolism
ISSN: 1096-7192
e-ISSN: 1096-7206
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein complexes involving transcription factors, co-regulators and additional nuclear proteins; these serve as targets for regulation by hormones and signaling pathways. Evidence that GH regulates transcription at multiple levels is exemplified by analysis of the proto-oncogene c-fos. Among the GH-regulated transcription factors on c-fos, C/EBPbeta appears to be key, since depletion of C/EBPbeta by RNA interference blocks the stimulation of c-fos by GH. The phosphorylation state of C/EBPbeta and its ability to activate transcription are regulated by GH through MAPK and PI3K/Akt-mediated signaling cascades. The acetylation of C/EBPbeta also contributes to its ability to activate c-fos transcription. These and other post-translational modifications of C/EBPbeta appear to be integrated for regulation of transcription by GH. The formation of nuclear proteins into complexes associated with DNA-bound transcription factors is also regulated by GH. Both C/EBPbeta and the co-activator p300 are recruited to c-fos in response to GH, altering c-fos promoter activation. In addition, GH rapidly induces spatio-temporal re-localization of C/EBPbeta within the nucleus. Thus, GH-regulated gene transcription mediated by C/EBPbeta reflects the integration of diverse mechanisms including post-translational modifications, modulation of protein complexes associated with DNA and re-localization of gene regulatory proteins. Similar integration involving other transcription factors, including Stats, appears to be a feature of regulation by GH of other gene targets.
Palabras clave: Gh , C/Ebpbeta , Gene Expression , Nucleoproteins , Transcription Factors
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/28539
URL: http://www.mgmjournal.com/article/S1096-7192(06)00349-0/fulltext
DOI: http://dx.doi.org/10.1016/j.ymgme.2006.10.006
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986646/
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Ceseña, Teresa I.; Cui, Tracy Xiao; Piwien Pilipuk, Graciela; Kaplani, Julianne; Calinescu, Anda Alexandra; et al.; Multiple mechanisms of growth hormone-regulated gene transcription; Elsevier; Molecular Genetics And Metabolism; 90; 2; -1-2007; 126-133
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