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dc.contributor.author
Luquita, A.  
dc.contributor.author
Urli, L.  
dc.contributor.author
Dominighini, A.  
dc.contributor.author
Svetaz, M. J.  
dc.contributor.author
Gennaro, Ana Maria  
dc.contributor.author
Volpintesta, R.  
dc.contributor.author
Palatnik, S.  
dc.contributor.author
Rasia, M.  
dc.date.available
2017-10-31T18:30:53Z  
dc.date.issued
2004-12  
dc.identifier.citation
Luquita, A.; Urli, L.; Dominighini, A.; Svetaz, M. J.; Gennaro, Ana Maria; et al.; Haemorheological variables as a rheumatoid arthritis activity indicator; IOS Press; Clinical Hemorheology And Microcirculation; 30; 1; 12-2004; 9-16  
dc.identifier.issn
1386-0291  
dc.identifier.uri
http://hdl.handle.net/11336/27269  
dc.description.abstract
Objective: To investigate if blood hyperviscosity in RA patients is due to a reduced erythrocyte deformability and, therefore, turning it into a reliable activity indicator, as well as a therapy follow-up marker for this pathology. Methods: (1) The haemorheological profile consisting of erythrocyte deformability, blood and plasma viscosity, and erythrocyte membrane fluidity was determined in 24 AR patients and 17 healthy controls. (2) A 4 year follow-up was carried on in 16 patients monitoring blood viscosity, erythrocyte deformability and biochemical variables in relation to clinical assessment of disease activity (Disease Activity Score “DAS 28-4”). Results: Erythrocyte deformability and membrane fluidity were impaired in RA patients compared to controls (p<0.001). Blood viscosity was significantly increased and correlated with the cell rigidity index (r=0.85, p<0.0000) in RA patients. The follow-up showed a good correlation between haemorheological parameters and DAS 28-4 during disease evolution. Conclusion: our results support the hypothesis that in RA, blood hyperviscosity is determined by deformability loss, which in turn is due to a membrane rigidization. This could evidenced that a widespread cell membrane damage is expressed through an impaired erythrocyte deformability, turning haemorheological parameters into reliable tools to study disease evolution. The follow-up study enabled us to confirm that erythrocyte deformability is an efficient indicator of rheumatoid arthritis activity.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
IOS Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject.classification
Otras Ciencias Físicas  
dc.subject.classification
Ciencias Físicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Haemorheological variables as a rheumatoid arthritis activity indicator  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-10-30T18:43:34Z  
dc.journal.volume
30  
dc.journal.number
1  
dc.journal.pagination
9-16  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Luquita, A.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Urli, L.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Dominighini, A.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Svetaz, M. J.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Gennaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: Volpintesta, R.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Palatnik, S.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Rasia, M.. Universidad Nacional de Rosario; Argentina  
dc.journal.title
Clinical Hemorheology And Microcirculation  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch571