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dc.contributor.author
Luquetti, Daniela
dc.contributor.author
Saltzman, Babette S.
dc.contributor.author
López Camelo, Jorge Santiago
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dc.contributor.author
Dutra, Maria da Graça
dc.contributor.author
Castilla, Eduardo Enrique
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dc.date.available
2017-10-13T20:27:05Z
dc.date.issued
2013-11
dc.identifier.citation
Luquetti, Daniela; Saltzman, Babette S.; López Camelo, Jorge Santiago; Dutra, Maria da Graça; Castilla, Eduardo Enrique; Risk factors and demographics for microtia in South America: a case-control analysis; Wiley; Birth Defects Research Part A: Clinical and Molecular Teratology; 97; 11; 11-2013; 736-743
dc.identifier.issn
1542-0752
dc.identifier.uri
http://hdl.handle.net/11336/26651
dc.description.abstract
BACKGROUND: The etiopathogenesis of microtia is still unknown in the majority of the cases, particularly for individuals presenting with isolated microtia. Our aim was to evaluate potential risk factors for this condition using a case–control approach. METHODS: We analyzed data from 1,194 live births with isolated microtia enrolled in the ECLAMC study (Estudio Colaborativo Latino Americano de Malformaciones Congénitas) from 1982 to 2011 and their respective controls. Odds ratios (ORs) were estimated with logistic regression models along with 95% confidence intervals for the resulting OR estimates controlling for the effects of potential confounders (sex, maternal age, hospital, and year of birth) for an adjusted OR (aOR). RESULTS: Multiparity was associated with a higher risk of microtia compared with primiparity (aOR, 1.5; 95% confidence interval [CI], 1.2–1.8), with women who had eight or more prior pregnancies having the highest risk (aOR, 2.8; 95% CI, 1.6–5.2). Women who presented with cold-like symptoms were at higher risk for microtia (aOR, 2.2; 95% CI, 1.2–3.9) as well as those that used tobacco or alcohol during pregnancy (aOR, 1.7; 95% CI, 1.1–2.6 and aOR, 1.4; 95% CI, 0.9–2.1, respectively). The association with alcohol use appeared to be limited to those women who reported binge drinking during pregnancy (aOR, 1.4; 95% CI, 0.7–3.1). Cases from hospitals at low altitude (<2500 m) tended to have more severe types of microtia than those from hospitals at high altitude. CONCLUSION: These results support the hypothesis that, in addition to teratogens, other nongenetic risk factors contribute to the occurrence of isolated microtia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Risk
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Factors
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Demographics
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Anotia
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Ear
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Epidemiology
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Microtia
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Nongenetic Risk Factors
dc.subject.classification
Ética Médica
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Risk factors and demographics for microtia in South America: a case-control analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-12T21:23:03Z
dc.identifier.eissn
1542-0760
dc.journal.volume
97
dc.journal.number
11
dc.journal.pagination
736-743
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Luquetti, Daniela. University of Washington; Estados Unidos. Seattle Children; Estados Unidos
dc.description.fil
Fil: Saltzman, Babette S.. Seattle Children; Estados Unidos
dc.description.fil
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.description.fil
Fil: Dutra, Maria da Graça. Instituto Oswaldo Cruz; Brasil
dc.description.fil
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Instituto Nacional de Genética Médica Populacional; Brasil
dc.journal.title
Birth Defects Research Part A: Clinical and Molecular Teratology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/bdra.23193/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/bdra.23193
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098829/
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