Artículo
Risk factors and demographics for microtia in South America: a case-control analysis
Luquetti, Daniela; Saltzman, Babette S.; López Camelo, Jorge Santiago
; Dutra, Maria da Graça; Castilla, Eduardo Enrique
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
11/2013
Editorial:
Wiley
Revista:
Birth Defects Research Part A: Clinical and Molecular Teratology
ISSN:
1542-0752
e-ISSN:
1542-0760
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
BACKGROUND: The etiopathogenesis of microtia is still unknown in the majority of the cases, particularly for individuals presenting with isolated microtia. Our aim was to evaluate potential risk factors for this condition using a case–control approach. METHODS: We analyzed data from 1,194 live births with isolated microtia enrolled in the ECLAMC study (Estudio Colaborativo Latino Americano de Malformaciones Congénitas) from 1982 to 2011 and their respective controls. Odds ratios (ORs) were estimated with logistic regression models along with 95% confidence intervals for the resulting OR estimates controlling for the effects of potential confounders (sex, maternal age, hospital, and year of birth) for an adjusted OR (aOR). RESULTS: Multiparity was associated with a higher risk of microtia compared with primiparity (aOR, 1.5; 95% confidence interval [CI], 1.2–1.8), with women who had eight or more prior pregnancies having the highest risk (aOR, 2.8; 95% CI, 1.6–5.2). Women who presented with cold-like symptoms were at higher risk for microtia (aOR, 2.2; 95% CI, 1.2–3.9) as well as those that used tobacco or alcohol during pregnancy (aOR, 1.7; 95% CI, 1.1–2.6 and aOR, 1.4; 95% CI, 0.9–2.1, respectively). The association with alcohol use appeared to be limited to those women who reported binge drinking during pregnancy (aOR, 1.4; 95% CI, 0.7–3.1). Cases from hospitals at low altitude (<2500 m) tended to have more severe types of microtia than those from hospitals at high altitude. CONCLUSION: These results support the hypothesis that, in addition to teratogens, other nongenetic risk factors contribute to the occurrence of isolated microtia.
Palabras clave:
Risk
,
Factors
,
Demographics
,
Anotia
,
Ear
,
Epidemiology
,
Microtia
,
Nongenetic Risk Factors
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Luquetti, Daniela; Saltzman, Babette S.; López Camelo, Jorge Santiago; Dutra, Maria da Graça; Castilla, Eduardo Enrique; Risk factors and demographics for microtia in South America: a case-control analysis; Wiley; Birth Defects Research Part A: Clinical and Molecular Teratology; 97; 11; 11-2013; 736-743
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