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Artículo

A Poly(3,4-ethylenedioxythiophene) Derivative Incorporating Ethynyl Moieties for Click Chemistry-Based Bioelectronics

Fenoy, Gonzalo EduardoIcon ; Lorenz, Christoph; Pasquale, Miguel AngelIcon ; Marmisollé, Waldemar AlejandroIcon ; Bäuerle, Peter; Azzaroni, OmarIcon ; Knoll, Wolfgang
Fecha de publicación: 07/2024
Editorial: American Chemical Society
Revista: Chemistry Of Materials
ISSN: 0897-4756
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

Efficiently integrating biological elements with the surface of organic semiconductors is a key objective in advancing the development of bioelectronic devices. In this work, we introduce the fabrication and functionalization of organic electrochemical transistors (OECTs) utilizing PEDOT-E as channel material, a poly(3,4-ethylenedioxythiophene) (PEDOT) derivative featuring pendant ethynyl moieties. First, the synthesis of the EDOT-E monomer and its electropolymerization onto Au interdigitated electrodes to produce PEDOT-E OECTs are detailed. Next, the film growth process is investigated by varying the number of electropolymerization cycles, leading to the optimization of the transistor fabrication protocol. The obtained devices exhibit lower threshold voltage values compared with state-of-the-art PEDOT-based OECTs. Furthermore, the ethynyl moieties are exploited for the click chemistry-based functionalization of the devices, enabling the incorporation of ferrocene redox probes. Next, biorecognition elements such as an azide-functionalized biotin are also anchored, yielding the acquisition of robust bioconstructs based on avidin–biotin interactions that are suitable for enzymatic biosensing. Last, azido-functionalized gelatin is “clicked” onto the transistors, not only enhancing their electronic features but also improving their biocompatibility for cell interfacing, a crucial step toward the further development of neural probes.
Palabras clave: Electrodes , Transistors , Polymers , Electropolymerization
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/262530
URL: https://pubs.acs.org/doi/10.1021/acs.chemmater.4c00989
DOI: http://dx.doi.org/10.1021/acs.chemmater.4c00989
Colecciones
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Fenoy, Gonzalo Eduardo; Lorenz, Christoph; Pasquale, Miguel Angel; Marmisollé, Waldemar Alejandro; Bäuerle, Peter; et al.; A Poly(3,4-ethylenedioxythiophene) Derivative Incorporating Ethynyl Moieties for Click Chemistry-Based Bioelectronics; American Chemical Society; Chemistry Of Materials; 36; 15; 7-2024; 7207-7221
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