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dc.contributor.author
Mochny, Cristiane R.
dc.contributor.author
Kincheski, Grasielle C.
dc.contributor.author
Molina, Víctor Alejandro
dc.contributor.author
Carobrez, Antonio P.
dc.date.available
2017-10-04T17:31:27Z
dc.date.issued
2012-09
dc.identifier.citation
Mochny, Cristiane R.; Kincheski, Grasielle C.; Molina, Víctor Alejandro; Carobrez, Antonio P.; Dorsolateral periaqueductal gray stimulation prior to retrieval potentiates a contextual fear memory in rats; Elsevier Science; Behavioural Brain Research; 237; 9-2012; 76-81
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/25872
dc.description.abstract
The association of a neutral context with an aversive stimulus, such as foot-shock, result in a contextual fear memory. A growing number of evidence have revealed that prior exposure to diverse threatening situations facilitates the encoding of fear memory during acquisition and such reports support the widespread notion that emotionally arousal results in stronger and long-lasting memories. However, few studies have investigated if a threatening experience can affect the recall and the persistence of such fear memory trace. To test the hypothesis that an emotionally negative experience could modify the retrieval of a memory and potentiate the expression of a fear memory, the present study used the chemical stimulation (microinjection of NMDA) of the dorsolateral periaqueductal gray matter (dlPAG) of rats in order to induce an aversive emotional state. Such stimulation was performed one day after a weak fear training protocol, and the fear expression was analyzed in subsequent re-exposures to the conditioned context. The results showed that the negative emotional state induced by the dlPAG stimulation enhanced the fear memory trace when this trace was reactivated one day after this aversive experience. Additionally, the potentiation of the fear response was contingent to the associated context since no potentiation was evident when NMDA-stimulated animals were subsequently placed in a non-associated context. Finally, the model suggests that the enhancement of fear responses is long-lasting since NMDA-treated animals performed a robust fear response six days after memory retrieval.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Sustancia Gris Periqueductal
dc.subject
Nmda
dc.subject
Fear Memory
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dorsolateral periaqueductal gray stimulation prior to retrieval potentiates a contextual fear memory in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-03T18:23:05Z
dc.journal.volume
237
dc.journal.pagination
76-81
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Mochny, Cristiane R.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Kincheski, Grasielle C.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Carobrez, Antonio P.. Universidade Federal de Santa Catarina; Brasil
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2012.09.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166432812005980
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