Artículo
Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes
Cejas, Jimena del Pilar
; Rosa, Antonio Sebastián
; González Paz, Agustín Nicolás
; Disalvo, Edgardo Anibal
; Frias, Maria de Los Angeles





Fecha de publicación:
02/2024
Editorial:
Elsevier Science Inc.
Revista:
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study analyses the insertion of Chlorogenic acid (CGA) in phosphatidylcholine (PC) membranes enriched with cholesterol (Chol).While cholesterol decreases the area per lipid and increases the dipole potential, CGA increases and decreases these values, respectively. When CGA is inserted into cholesterol-containing DMPC membranes, these effects cancel out, resulting in values that overlap with those of DMPC monolayers without Chol and CGA. The presence of CGA also compensates the increase of dipole potential produced by Chol which can be explain as a consequence of the orientation of CGA molecule at the interphase opposing the cholesterol dipole moieties and water dipoles. This compensatory effect is less effective when lipids lack carbonyl groups (CO). When monolayers are composed by unsaturated PCs the Chol compensation is found at higher concentrations of CGA due to the direct interaction between CGA and Chol.These results suggest that cholesterol modulates the interaction and distribution of CGA in the lipid membrane, which may have implications for its biological activity.
Palabras clave:
Lipid Monolayer
,
Chlorogenic Acid
,
Cholesterol
,
Surface Pressure
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Articulos (CIBAAL)
Articulos de CENTRO DE INVESTIGACION EN BIOFISICA APLICADA Y ALIMENTOS
Articulos de CENTRO DE INVESTIGACION EN BIOFISICA APLICADA Y ALIMENTOS
Citación
Cejas, Jimena del Pilar; Rosa, Antonio Sebastián; González Paz, Agustín Nicolás; Disalvo, Edgardo Anibal; Frias, Maria de Los Angeles; Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes; Elsevier Science Inc.; Archives of Biochemistry and Biophysics; 753; 2-2024; 1-7
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