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dc.contributor.author
Schumacher, Michael
dc.contributor.author
Sitruk Ware, Regine
dc.contributor.author
de Nicola, Alejandro Federico
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dc.date.available
2017-09-29T19:34:48Z
dc.date.issued
2008-12
dc.identifier.citation
Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico; Progesterone and progestins: neuroprotection and myelin repair; Elsevier; Current Opinion In Pharmacology; 8; 6; 12-2008; 740-746
dc.identifier.issn
1471-4892
dc.identifier.uri
http://hdl.handle.net/11336/25465
dc.description.abstract
Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.relation
Erratum in Curr Opin Pharmacol. 2009 Apr;9(2):227
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Progesterone
dc.subject
Progesterone Receptors
dc.subject
Neuroprotection
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Hormone Replacement Therapy
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Progesterone and progestins: neuroprotection and myelin repair
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:30:12Z
dc.identifier.eissn
1471-4973
dc.journal.volume
8
dc.journal.number
6
dc.journal.pagination
740-746
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Schumacher, Michael. Inserm; Francia
dc.description.fil
Fil: Sitruk Ware, Regine. The Rockefeller University; Estados Unidos
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.journal.title
Current Opinion In Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1471489208001586
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.coph.2008.10.002
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