Artículo
Progesterone and progestins: neuroprotection and myelin repair
Fecha de publicación:
12/2008
Editorial:
Elsevier
Revista:
Current Opinion In Pharmacology
ISSN:
1471-4892
e-ISSN:
1471-4973
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico; Progesterone and progestins: neuroprotection and myelin repair; Elsevier; Current Opinion In Pharmacology; 8; 6; 12-2008; 740-746
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