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Capítulo de Libro

Beyond Acute Traumatic Brain Injury: Molecular Implications of Associated Neuroinflammation in Higher-Order Cognitive Processes

Título del libro: Psychiatry and Neuroscience Update: From Epistemology to Clinical Psychiatry

Montivero, AgustinIcon ; Ghersi, Marisa SoledadIcon ; Catalan Figueroa, Johanna FrancescaIcon ; Formica, María LinaIcon ; Camacho, Nahuel MatiasIcon ; Culasso, Antonella F.; Hereñú, Claudia BeatrizIcon ; Palma, Santiago DanielIcon ; Perez, Mariela FernandaIcon
Otros responsables: Gargiulo, Pascual AngelIcon ; Mesones Arroyo, Humberto Luis
Fecha de publicación: 2021
Editorial: Springer Nature Switzerland AG
ISBN: 978-3-030-61721-9
Idioma: Inglés
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Traumatic brain injury (TBI) is a worldwide major clinical problem affecting millions of individuals annually which report chronic disabilities long after the initial injury event. Besides the early mechanical damage, TBI can induce a process of secondary injury which can lead to long-term neurological and neuropsychiatric sequelae. Aside from the established risk for neurodegenerative disease, the most frequently reported behavioral, affective, or psychological changes concerned irritability, bad temper, tiredness, depression, rapid mood change, and anxiety. These changes can impact on higher-order cognitive processes. Secondary brain injury is caused mainly due to metabolic, synaptic, and vascular alterations, along with neuroinflammatory processes and oxidative stress. These events are associated to excitotoxicity that produces an ionic imbalance and cellular edema. Finally, the unfolded protein response is triggered, as well as the generation of toxic and pro-inflammatory mediators, which in turn may induce reticulum stress, apoptosis, and/or necrosis. No pharmacological therapy has proven to be useful against secondary injury. Current therapeutic strategies in the management of TBI are limited to decrease intracranial pressure and thus improving cerebral blood flow. In this chapter we reviewed the molecular mechanisms underlying secondary injury that can be explored as possible targets for development of new therapeutic agents to treat many of the long-term sequelae and provide life improvements for those suffering from TBI. In addition, the different micro-/nanotechnologies and devices that have been tested as strategies for drug delivery were discussed.
Palabras clave: Traumatic brain injury , Secondary injury , Neuroinflammation , Cognitive deficits , Neurotoxicity , Trauma therapy
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/251685
URL: https://link.springer.com/chapter/10.1007/978-3-030-61721-9_20
DOI: https://doi.org/10.1007/978-3-030-61721-9_20
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Capítulos de libros(IFEC)
Capítulos de libros de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Capítulos de libros(UNITEFA)
Capítulos de libros de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Montivero, Agustin; Ghersi, Marisa Soledad; Catalan Figueroa, Johanna Francesca; Formica, María Lina; Camacho, Nahuel Matias; et al.; Beyond Acute Traumatic Brain Injury: Molecular Implications of Associated Neuroinflammation in Higher-Order Cognitive Processes; Springer Nature Switzerland AG; 4; 2021; 237-259
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