Capítulo de Libro
Beyond Acute Traumatic Brain Injury: Molecular Implications of Associated Neuroinflammation in Higher-Order Cognitive Processes
Título del libro: Psychiatry and Neuroscience Update: From Epistemology to Clinical Psychiatry
Montivero, Agustin
; Ghersi, Marisa Soledad
; Catalan Figueroa, Johanna Francesca
; Formica, María Lina
; Camacho, Nahuel Matias
; Culasso, Antonella F.; Hereñú, Claudia Beatriz
; Palma, Santiago Daniel
; Perez, Mariela Fernanda








Fecha de publicación:
2021
Editorial:
Springer Nature Switzerland AG
ISBN:
978-3-030-61721-9
Idioma:
Inglés
Clasificación temática:
Resumen
Traumatic brain injury (TBI) is a worldwide major clinical problem affecting millions of individuals annually which report chronic disabilities long after the initial injury event. Besides the early mechanical damage, TBI can induce a process of secondary injury which can lead to long-term neurological and neuropsychiatric sequelae. Aside from the established risk for neurodegenerative disease, the most frequently reported behavioral, affective, or psychological changes concerned irritability, bad temper, tiredness, depression, rapid mood change, and anxiety. These changes can impact on higher-order cognitive processes. Secondary brain injury is caused mainly due to metabolic, synaptic, and vascular alterations, along with neuroinflammatory processes and oxidative stress. These events are associated to excitotoxicity that produces an ionic imbalance and cellular edema. Finally, the unfolded protein response is triggered, as well as the generation of toxic and pro-inflammatory mediators, which in turn may induce reticulum stress, apoptosis, and/or necrosis. No pharmacological therapy has proven to be useful against secondary injury. Current therapeutic strategies in the management of TBI are limited to decrease intracranial pressure and thus improving cerebral blood flow. In this chapter we reviewed the molecular mechanisms underlying secondary injury that can be explored as possible targets for development of new therapeutic agents to treat many of the long-term sequelae and provide life improvements for those suffering from TBI. In addition, the different micro-/nanotechnologies and devices that have been tested as strategies for drug delivery were discussed.
Items relacionados
Mostrando titulos relacionados por título, autor y tema.
-
Capítulo de Libro Fearing Parkinson’s Disease: Relationships Between Cognition and EmotionTítulo del libro: Psychiatry and Neuroscience UpdateHerrera, Macarena Lorena ; Champarini, Leandro Gabriel ; Otamendi, Andrea; Hereñú, Claudia Beatriz - Otros responsables: Gargiulo, Pascual Angel Mesones Arroyo, Humberto Luis - (Springer Nature Switzerland AG, 2021)
-
Capítulo de Libro A Summary of the Developmental Trajectory of Executive Functions from Birth to AdulthoodTítulo del libro: Psychiatry and Neuroscience UpdateKorzeniowski, Celina Graciela ; Ison, Mirta Susana ; Difabio, Hilda Emilia - Otros responsables: Gargiulo, Pascual Angel Mesones Arroyo, Humberto Luis - (Springer Nature Switzerland AG, 2021)
Archivos asociados
Licencia
Identificadores
Colecciones
Capítulos de libros(IFEC)
Capítulos de libros de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Capítulos de libros de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Capítulos de libros(UNITEFA)
Capítulos de libros de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Capítulos de libros de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Montivero, Agustin; Ghersi, Marisa Soledad; Catalan Figueroa, Johanna Francesca; Formica, María Lina; Camacho, Nahuel Matias; et al.; Beyond Acute Traumatic Brain Injury: Molecular Implications of Associated Neuroinflammation in Higher-Order Cognitive Processes; Springer Nature Switzerland AG; 4; 2021; 237-259
Compartir
Altmétricas