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dc.contributor.author
Cardinaletti, Claudia
dc.contributor.author
Mattioli, Laura
dc.contributor.author
Ghelfi, Francesca
dc.contributor.author
Del Bello, Fabio
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Gianella, Mario
dc.contributor.author
Bruzzone, Ariana
dc.contributor.author
Paris, Hervé
dc.contributor.author
Perfumi, Marina
dc.contributor.author
Piergentili, Alessandro
dc.contributor.author
Quaglia, Wilma
dc.contributor.author
Pigini, Maria
dc.date.available
2017-09-19T15:04:29Z
dc.date.issued
2009-11-03
dc.identifier.citation
Cardinaletti, Claudia; Mattioli, Laura; Ghelfi, Francesca; Del Bello, Fabio; Gianella, Mario; et al.; Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?; American Chemical Society; Journal of Medicinal Chemistry; 52; 22; 3-11-2009; 7319-7322
dc.identifier.issn
0022-2623
dc.identifier.uri
http://hdl.handle.net/11336/24561
dc.description.abstract
The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided alpha(2)-adrenergic (AR) ligands endowed with significant alpha(2C)-agonism/alpha(2A)-antagonism. Similar behavior was displayed by cirazoline (12). For their positive morphine analgesia modulation (due to alpha(2C)-AR stimulation) and sedation overcoming (due to alpha(2A)-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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Patología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-13T20:40:19Z
dc.identifier.eissn
1520-4804
dc.journal.volume
52
dc.journal.number
22
dc.journal.pagination
7319-7322
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Cardinaletti, Claudia. Università degli Studi di Camerino; Italia
dc.description.fil
Fil: Mattioli, Laura. Università degli Studi di Camerino; Italia
dc.description.fil
Fil: Ghelfi, Francesca. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Del Bello, Fabio. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Gianella, Mario. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Bruzzone, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Paris, Hervé. Inserm; Francia
dc.description.fil
Fil: Perfumi, Marina. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Piergentili, Alessandro. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Quaglia, Wilma. Università degli Studi di Camerino; Francia
dc.description.fil
Fil: Pigini, Maria. Università degli Studi di Camerino; Francia
dc.journal.title
Journal of Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jm901262f
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/jm901262f
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/19886609
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