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dc.contributor.author Cardinaletti, Claudia
dc.contributor.author Mattioli, Laura
dc.contributor.author Ghelfi, Francesca
dc.contributor.author Del Bello, Fabio
dc.contributor.author Gianella, Mario
dc.contributor.author Bruzzone, Ariana
dc.contributor.author Paris, Hervé
dc.contributor.author Perfumi, Marina
dc.contributor.author Piergentili, Alessandro
dc.contributor.author Quaglia, Wilma
dc.contributor.author Pigini, Maria
dc.date.available 2017-09-19T15:04:29Z
dc.date.issued 2009-11-03
dc.identifier.citation Cardinaletti, Claudia; Mattioli, Laura; Ghelfi, Francesca; Del Bello, Fabio; Gianella, Mario; et al.; Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?; American Chemical Society; Journal of Medicinal Chemistry; 52; 22; 3-11-2009; 7319-7322
dc.identifier.issn 0022-2623
dc.identifier.uri http://hdl.handle.net/11336/24561
dc.description.abstract The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided alpha(2)-adrenergic (AR) ligands endowed with significant alpha(2C)-agonism/alpha(2A)-antagonism. Similar behavior was displayed by cirazoline (12). For their positive morphine analgesia modulation (due to alpha(2C)-AR stimulation) and sedation overcoming (due to alpha(2A)-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-13T20:40:19Z
dc.identifier.eissn 1520-4804
dc.journal.volume 52
dc.journal.number 22
dc.journal.pagination 7319-7322
dc.journal.pais Estados Unidos
dc.journal.ciudad Washington
dc.description.fil Fil: Cardinaletti, Claudia. Università degli Studi di Camerino; Italia
dc.description.fil Fil: Mattioli, Laura. Università degli Studi di Camerino; Italia
dc.description.fil Fil: Ghelfi, Francesca. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Del Bello, Fabio. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Gianella, Mario. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Bruzzone, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Paris, Hervé. Inserm; Francia
dc.description.fil Fil: Perfumi, Marina. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Piergentili, Alessandro. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Quaglia, Wilma. Università degli Studi di Camerino; Francia
dc.description.fil Fil: Pigini, Maria. Università degli Studi di Camerino; Francia
dc.journal.title Journal of Medicinal Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jm901262f
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/jm901262f
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/19886609


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)