Artículo

Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?

Cardinaletti, Claudia; Mattioli, Laura; Ghelfi, Francesca; Del Bello, Fabio; Gianella, Mario; Bruzzone, ArianaIcon ; Paris, Hervé; Perfumi, Marina; Piergentili, Alessandro; Quaglia, Wilma; Pigini, Maria
Fecha de publicación: 03/11/2009
Editorial: American Chemical Society
Revista: Journal of Medicinal Chemistry
ISSN: 0022-2623
e-ISSN: 1520-4804
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided alpha(2)-adrenergic (AR) ligands endowed with significant alpha(2C)-agonism/alpha(2A)-antagonism. Similar behavior was displayed by cirazoline (12). For their positive morphine analgesia modulation (due to alpha(2C)-AR stimulation) and sedation overcoming (due to alpha(2A)-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine.
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/24561
URL: http://pubs.acs.org/doi/abs/10.1021/jm901262f
DOI: http://dx.doi.org/10.1021/jm901262f
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Cardinaletti, Claudia; Mattioli, Laura; Ghelfi, Francesca; Del Bello, Fabio; Gianella, Mario; et al.; Might adrenergic α2C-agonists/α2A-antagonists become novel therapeutic tools for pain treatment with morphine?; American Chemical Society; Journal of Medicinal Chemistry; 52; 22; 3-11-2009; 7319-7322
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