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dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Toscano, Marta Alicia
dc.date.available
2017-09-18T20:51:15Z
dc.date.issued
2009-05
dc.identifier.citation
Rabinovich, Gabriel Adrián; Toscano, Marta Alicia; Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation; Macmillan Publisher Limited; Nature Reviews Immunology; 9; 5; 5-2009; 338-352
dc.identifier.issn
1474-1733
dc.identifier.uri
http://hdl.handle.net/11336/24530
dc.description.abstract
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Macmillan Publisher Limited
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Glycoimmunology
dc.subject
Galectins
dc.subject
Adaptive Immunity
dc.subject
Tolerance
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-13T20:40:22Z
dc.identifier.eissn
1474-1741
dc.journal.volume
9
dc.journal.number
5
dc.journal.pagination
338-352
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Nature Reviews Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nri/journal/v9/n5/full/nri2536.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nri2536
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