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dc.contributor.author
Salgueiro, María Jimena  
dc.contributor.author
Duran, Hebe Alicia  
dc.contributor.author
Palmieri, M.  
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Pirchio, R.  
dc.contributor.author
Nicolini, J.  
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Ughetti, R.  
dc.contributor.author
Papparella, M. L.  
dc.contributor.author
Casale, G.  
dc.contributor.author
Zubillaga, Marcela Beatriz  
dc.date.available
2024-09-19T11:36:11Z  
dc.date.issued
2008-03  
dc.identifier.citation
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; et al.; Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 66; 3; 3-2008; 303-309  
dc.identifier.issn
0969-8043  
dc.identifier.uri
http://hdl.handle.net/11336/244595  
dc.description.abstract
The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
32P  
dc.subject
BRACHYTHERAPY  
dc.subject
SKIN CANCER  
dc.subject
PATCH  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-09-18T13:04:28Z  
dc.journal.volume
66  
dc.journal.number
3  
dc.journal.pagination
303-309  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina  
dc.description.fil
Fil: Duran, Hebe Alicia. Universidad Nacional de San Martín; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Palmieri, M.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina  
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Fil: Pirchio, R.. Comisión Nacional de Energía Atómica; Argentina  
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Fil: Nicolini, J.. No especifíca;  
dc.description.fil
Fil: Ughetti, R.. No especifíca;  
dc.description.fil
Fil: Papparella, M. L.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina  
dc.description.fil
Fil: Casale, G.. No especifíca;  
dc.description.fil
Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Applied Radiation and Isotopes  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969804307002825  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apradiso.2007.09.008