Artículo
Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
Salgueiro, María Jimena; Duran, Hebe Alicia
; Palmieri, M.; Pirchio, R.; Nicolini, J.; Ughetti, R.; Papparella, M. L.; Casale, G.; Zubillaga, Marcela Beatriz
; Palmieri, M.; Pirchio, R.; Nicolini, J.; Ughetti, R.; Papparella, M. L.; Casale, G.; Zubillaga, Marcela Beatriz
Fecha de publicación:
03/2008
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Applied Radiation and Isotopes
ISSN:
0969-8043
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.
Palabras clave:
32P
,
BRACHYTHERAPY
,
SKIN CANCER
,
PATCH
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480.0Kb
Formato:
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Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; et al.; Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 66; 3; 3-2008; 303-309
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