Artículo

Screening of Catalytically Active Microorganisms for the Synthesis of 6-Modified Purine Nucleosides

Trelles, Jorge AbelIcon ; Valino, Ana LauraIcon ; Runza, V.; Lewkowicz, Elizabeth SandraIcon ; Iribarren, Adolfo MarceloIcon
Fecha de publicación: 06/2005
Editorial: Springer
Revista: Biotechnology Letters
ISSN: 0141-5492
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus (ATCC 12980) was found to be the best strain for this purpose.
Palabras clave: NUCLEOSIDES , TRANSGLYCOSYLATION , MICROORGANISMS , RIBONUCLEOSIDES
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/244236
URL: https://link.springer.com/article/10.1007/s10529-005-5628-7
DOI: http://dx.doi.org/10.1007/s10529-005-5628-7
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Trelles, Jorge Abel; Valino, Ana Laura; Runza, V.; Lewkowicz, Elizabeth Sandra; Iribarren, Adolfo Marcelo; Screening of Catalytically Active Microorganisms for the Synthesis of 6-Modified Purine Nucleosides; Springer; Biotechnology Letters; 27; 11; 6-2005; 759-763
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