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dc.contributor.author
Valtorta, Silvia Elsa  
dc.contributor.author
Scaglione, María Cristina  
dc.contributor.author
Acosta, P.  
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Coronel, J. E.  
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Beldomenico, Horacio Ramon  
dc.contributor.author
Boggio, Juan Carlos  
dc.date.available
2024-09-12T12:26:46Z  
dc.date.issued
2005-09  
dc.identifier.citation
Valtorta, Silvia Elsa; Scaglione, María Cristina; Acosta, P.; Coronel, J. E.; Beldomenico, Horacio Ramon; et al.; Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer; Springer; International Journal Of Biometeorology; 50; 3; 9-2005; 133-138  
dc.identifier.issn
0020-7128  
dc.identifier.uri
http://hdl.handle.net/11336/244123  
dc.description.abstract
The objective was to investigate circadian variations of blood and milk lead toxicokinetics in dairy cows in summer. Twenty lactating Holstein animals were randomly assigned to 4 treatments, corresponding to different hours after onset of light (HALO): 2, 8, 14 and 20. Cows received a single intravenous administration of 2.5 mg/kg lead as lead acetate. Blood and milk samples were taken and analyzed by atomic absorption spectrophotometry. For each toxicokinetic parameter, a one-way analysis of variance was performed to outline the existence of daily variations. Significant blood differences as a function of HALO were found for the hybrid constant of distribution (á), hybrid constant of elimination (â), elimination half-life (t1=2_ ), area under the curve (AUC), volume of distribution at steady state (Vss) and clearance (ClB) (p<0.05). Half-life of elimination presented two peaks at 2 and 14 HALO. Milk data showed significant differences for maximum concentration and AUC (p<0.05). The ratio AUCmilk/ AUCblood was utilized to estimate penetration of lead in milk. It differed significantly along the day (p<0.05). Milk data for the significant parameters could be fitted to circadian rhythms. No circadian rhythms were detected in blood parameters or in the ratio AUCmilk/AUCblood.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Intravenous administration  
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Intravenous administration  
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Summer  
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Dairy cows  
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Circadian rhythms  
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Investigación Climatológica  
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Ciencias de la Tierra y relacionadas con el Medio Ambiente  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-09-11T12:42:38Z  
dc.journal.volume
50  
dc.journal.number
3  
dc.journal.pagination
133-138  
dc.journal.pais
Alemania  
dc.journal.ciudad
Heidelberg  
dc.description.fil
Fil: Valtorta, Silvia Elsa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina  
dc.description.fil
Fil: Scaglione, María Cristina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina  
dc.description.fil
Fil: Acosta, P.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina  
dc.description.fil
Fil: Coronel, J. E.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina  
dc.description.fil
Fil: Beldomenico, Horacio Ramon. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina  
dc.description.fil
Fil: Boggio, Juan Carlos. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina  
dc.journal.title
International Journal Of Biometeorology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00484-005-0001-z  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00484-005-0001-z