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dc.contributor.author
Valtorta, Silvia Elsa
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Scaglione, María Cristina
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Acosta, P.
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Coronel, J. E.
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Beldomenico, Horacio Ramon
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Boggio, Juan Carlos
dc.date.available
2024-09-12T12:26:46Z
dc.date.issued
2005-09
dc.identifier.citation
Valtorta, Silvia Elsa; Scaglione, María Cristina; Acosta, P.; Coronel, J. E.; Beldomenico, Horacio Ramon; et al.; Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer; Springer; International Journal Of Biometeorology; 50; 3; 9-2005; 133-138
dc.identifier.issn
0020-7128
dc.identifier.uri
http://hdl.handle.net/11336/244123
dc.description.abstract
The objective was to investigate circadian variations of blood and milk lead toxicokinetics in dairy cows in summer. Twenty lactating Holstein animals were randomly assigned to 4 treatments, corresponding to different hours after onset of light (HALO): 2, 8, 14 and 20. Cows received a single intravenous administration of 2.5 mg/kg lead as lead acetate. Blood and milk samples were taken and analyzed by atomic absorption spectrophotometry. For each toxicokinetic parameter, a one-way analysis of variance was performed to outline the existence of daily variations. Significant blood differences as a function of HALO were found for the hybrid constant of distribution (á), hybrid constant of elimination (â), elimination half-life (t1=2_ ), area under the curve (AUC), volume of distribution at steady state (Vss) and clearance (ClB) (p<0.05). Half-life of elimination presented two peaks at 2 and 14 HALO. Milk data showed significant differences for maximum concentration and AUC (p<0.05). The ratio AUCmilk/ AUCblood was utilized to estimate penetration of lead in milk. It differed significantly along the day (p<0.05). Milk data for the significant parameters could be fitted to circadian rhythms. No circadian rhythms were detected in blood parameters or in the ratio AUCmilk/AUCblood.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Intravenous administration
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Intravenous administration
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Summer
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Dairy cows
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Circadian rhythms
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Investigación Climatológica
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-09-11T12:42:38Z
dc.journal.volume
50
dc.journal.number
3
dc.journal.pagination
133-138
dc.journal.pais
Alemania
dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Valtorta, Silvia Elsa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
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Fil: Scaglione, María Cristina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
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Fil: Acosta, P.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
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Fil: Coronel, J. E.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
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Fil: Beldomenico, Horacio Ramon. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
dc.description.fil
Fil: Boggio, Juan Carlos. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
International Journal Of Biometeorology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00484-005-0001-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00484-005-0001-z
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